氨基糖甙类抗生素耳毒性的研究进展  

Ototoxic Research Progress of Aminoglycoside Antibiotics

作　　者：李昱[1] 王爱梅[1] 

机构地区：[1]辽宁医学院生理学教研室,辽宁锦州121001

出　　处：《医学综述》2008年第3期459-461,共3页Medical Recapitulate

基　　金：辽宁省教育厅科学研究计划资助(202173374);辽宁省博士科研启动基金项目(20031086)

摘　　要：氨基糖甙类抗生素(AmAn)由于具有高效、廉价等优点,因此,半个多世纪以来一直成为抗革兰阴性和阳性细菌的有效。然而,由于AmAn具有耳毒性、肾毒性等副作用,从而大大限制了其在临床中的应用。近年来,科研工作者对AmAn耳毒性作用进行了一系列的研究并取得了一些进展。现就AmAn耳毒性机制、预防药物以及动物模型等方面的研究进行综述。Aminoglycoside Antibiotics has some advantages of high efficacy, low proce and so on. So it has been used as active drugs in treating infection of gram-negative and gram-positive bacteria. But its clinical application is mostly limited because of its side effect of ototoxicity and nephrotoxicity. A series of studies about its ototoxicity has been carried out by scholars and some progresses had been achieved. This article reviews studies of ototoxicity about its mechanism,prophylactic agent,animal model and so on.

关 键 词：耳聋 氨基糖甙类 耳毒性 耳蜗 

分 类 号：R764.43[医药卫生—耳鼻咽喉科] R978.12[医药卫生—临床医学]