帕金森病患者眼球运动预测性控制的临床观察  

Predictive ocular motor control in Parkinson＇s disease

作　　者：应黎[1] 刘振国[1] 陈伟[1] 干静[1] 王文安[1] 

机构地区：[1]上海交通大学医学院附属新华医院神经内科,200092

出　　处：《中华医学杂志》2008年第7期442-444,共3页National Medical Journal of China

基　　金：国家教育部留学回国人员基金资助项目;上海市教委发展基金资助项目（06BZ048）;上海市浦江人才计划基金资助项目

摘　　要：目的研究帕金森病（PD）患者眼球运动预测性控制能力，探讨其临床意义。方法利用视频眼震电图（VNG）对早中期原发性PD患者和年龄、性别相匹配的正常人做可预测性眼球扫视运动，比较两组的扫视潜伏期。结果在随机性扫视方案中，PD组和对照组扫视潜伏期分别为284ms±58ms和236ms±37ms，两者比较差异有统计学意义（P=0．003）；在可预测性扫视方案中，PD组和对照组的扫视潜伏期分别为150ms±138ms和59ms±102ms，两组差异有统计学意义（P=0．002）；在可预测扫视方案中，PD组出现预见性扫视的次数占21％，对照组则占31％，两者相比，差异有统计学意义（P=0．003）。结论PD患者存在眼球运动预见性机制缺陷，表明PD在疾病早期可能出现部分认知功能障碍。Objective To investigate the changes of predictive ocular motor function in the patients with Parkinson＇s disease （PD）, and to discuss its clinical value. Methods Videonystagmography （VNG） was used to examine 24 patients with idiopathic Parkinson＇s disease, 15 males and 9 females, aged 61 ± 6 （50-69）, and 24 sex and age-matched healthy control subjects on random ocular saccade （ with the target moving at random intervals to random positions） and predictive ocular saccade （ with the 1.25-second light target moving 10 degrees right or left from the center）. Result In the random ocular saccade program, the latency of saccade of the PD patients was 284 ms ± 58 ms, significantly longer than that of the healthy controls （236 ms ± 37 ms, P = 0. 003 ）. In the predictive ocular saccade pattern, the latency of saccades the PD patients was 150 ms ± 138 ms, significantly longer than that of the healthy controls （59 ms±102 ms, P = 0. 002）. The appearance rate of predictive saccades （ with the latency of saccade 〈 80 ms） in the PD group was 21%, significantly lower than that in the control group （ 31%, P = 0. 003 ）. Conclusion There is dysfunction of predictive ocular motor control in the PD patients, and the cognitive function may be impaired at the early stage of PD.

关 键 词：帕金森病 扫视 视频眼震电图 

分 类 号：R686[医药卫生—骨科学]