吉美拉西(gimeracil)多晶型的制备及其鉴定  

Preparation and identification of gimeracil polymorphs

作　　者：王浦海[1] 刘宇[1] 丁逸梅[1] 杭庆伟[2] 

机构地区：[1]南京工业大学江苏省药物研究所,江苏南京210009 [2]南京大学化学化工学院,江苏南京210008

出　　处：《中国药物化学杂志》2008年第1期44-47,共4页Chinese Journal of Medicinal Chemistry

摘　　要：目的研究抗肿瘤药吉美拉西的多晶型。方法分别以"碱溶-酸析"法或甲醇、乙醇等有机溶剂重结晶法,制备吉美拉西的多晶型。通过热重分析、差示扫描量热分析、红外光谱、粉末X-射线衍射谱等对吉美拉西多晶型进行鉴定。结果与结论吉美拉西结晶至少存在两种不同的晶型。Aim To study gimeracil polymorphs. Methods Gimeracil polymorphs were prepared by alkali-acid treatment or recrystallization with EtOH, MeOH, etc. Character of gimeracil polymorphs was detected by TGA, DSC, IR, and X-ray powder diffraction. Results and conclusion There were at least two different crystal forms of gimeracil.

关 键 词：吉美拉西 多晶型 抗肿瘤药 复方替加氟 

分 类 号：R94[医药卫生—药剂学]