黄豆苷元液体硬胶囊的处方筛选及体外溶出度考察  

Formulation selection and study of dissolution in vitro on liquid hard capsules of daidzein

作　　者：宋扬[1] 常笛[1] 王东凯[1] 杨秀丽[1] 王丽君[1] 王海凤[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2008年第2期96-100,共5页Journal of Shenyang Pharmaceutical University

摘　　要：目的通过液体硬胶囊技术提高黄豆苷元的体外溶出度。方法设计了一系列处方测定黄豆苷元液体胶囊的平衡水量;采用紫外分光光度法测定黄豆苷元液体硬胶囊的体外溶出度,筛选出最适宜的PVP K30用量;采用HPLC法测定黄豆苷元液体硬胶囊的含量。结果最佳处方的平衡水量为8%,黄豆苷元与PVP K30的最优质量比为1∶7;黄豆苷元液体硬胶囊的体外溶出度45 min可达到90%以上,含量质量分数为100.03%。结论通过加入一定量的水使胶囊壳和内容物之间达到水分的平衡,解决了吸水性辅料和硬胶囊壳的相容性问题;制备的黄豆苷元液体硬胶囊有较高的体外溶出度。Objective To improve the dissolution rate of daidzein by liquid hard capsules technology. Methods The balanced amount of water was obtained, and the best amount of PVP K30 was selected. The dissolution rate of capsules was determined by UV method, and the content of the capsules was obtained by HPLC. Results The optimal balanced amount of water was 8 %, and the best ratio of daidzein and PVP K30 was 1 ： 7. The dissolution of capsules in vitro was higher than 90 % at 45 min, the content was 100.03 %. Conclusions The problem on the compatibility of hydrophilic vehicles and hard capsules is resolved by adding balanced amount of water. The obtained liquid hard capsules have a high dissolution in vitro .

关 键 词：黄豆苷元 液体硬胶囊 溶出度 

分 类 号：R94[医药卫生—药剂学]