取代邻羟基二苯甲酮的合成1,3,5-三甲氧基苯与对位取代苯甲酰氯的Friedel-Crafts反应  

Synthesis of Substituted o Hydroxybenzophenone The F C Reaction of 1,3,5 Trimethoxybenzene with p Substituted Benzoyl Chlorides

作　　者：邱国福[1,2] 李宗清[1,2] 李静 邱玉珠 胡宏纹[1,2] 

机构地区：[1]湖北医科大学化学教研室 [2]南京大学化学系

出　　处：《合成化学》1997年第1期54-56,共3页Chinese Journal of Synthetic Chemistry

摘　　要：控制反应物摩尔比、反应温度和反应时间，１，３，５－三甲氧基苯与对位取代苯甲酰氯发生Ｆｒｉｅｄｅｌ－Ｃｒａｆｔｓ反应，选择性地合成了２－羟基－４，６－二甲氧基－４－Ｒ－二苯甲酮和３－（４″－Ｒ－苯甲酰基）－２－羟基－４，６－二甲氧基－４－Ｒ－二苯甲酮。反应条件温和，产率较高。化合物的结构都经元素分析、１ＨＮＭＲ和ＩＲ确定。The Friedel Crafts reaction of 1,3,5 trimethoxybenzene with p substituted benzoyl chlorides can be used to synthesize selectively 2 hydroxy 4,6 dimethoxy 4 R benzophenones and 3 (4″ R benzoyl) 2 hydroxyl 4,6 dimethoxy 4 R benzophenones by controlling molar ratio of reactants, reaction time and temperature. Synthetic condition was mild and the yields were 37%～81%. The structures of all compounds were identified by elemental analysis, 1H NMR and IR.

关 键 词：取代邻羟基 二苯甲酮 合成 F-C反应 

分 类 号：O625.4[理学—有机化学]