藏、汉族妇女子宫内膜异位症相关血管内皮生长因子受体表达差异研究  

Expression of vascular endothelial growth factors receptors difference between women in Tibetan and Han nationalities of endometriosis

作　　者：尼玛卓玛 王黎娜[2] 普布次仁 德吉卓玛 胡正谦 李亚里[3] 

机构地区：[1]武警西藏总队医院妇产科,拉萨850001 [2]武警总医院妇产科 [3]中国人民解放军总医院妇产科

出　　处：《中华妇幼临床医学杂志（电子版）》2008年第1期18-20,共3页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：国家自然科学基金重点资助课题(编号:39830350)

摘　　要：目的探讨血管内皮生长因子受体(VEGFR)、胎肝激酶受体(KDR/flk-1)在藏、汉族妇女子宫内膜异位症(EM)患者的异位、在位子宫内膜及正常子宫内膜组织中的表达差异。方法采用逆转录聚合酶链反应(RT-PCR)法,随机选取30例藏族EM患者的子宫内膜组织、卵巢子宫内膜囊肿、盆底内膜异位组织(研究组),检测VEGFR-2的阳性表达率。同期选择30例汉族EM患者的子宫内膜组织、卵巢子宫内膜囊肿、盆底内膜异位组织作为对照(对照组),检测VEGFR-2的阳性表达率,对两组进行对照分析。结果藏、汉族妇女EM患者的在位内膜、异位内膜中,KDR mRNA明显表达,差异有显著意义(P<0.05);藏、汉两组患者KDR mRNA的阳性表达率比较,差异无显著意义(P>0.05)。结论KDR mRNA在EM在位内膜和异位内膜中,有明显表达,可能与VEGFR参与EM血管生成,促使异位病灶远处转移、种植、浸润相关;KDR mRNA在藏、汉族EM患者中的阳性表达率比较,差异无显著意义。可见,EM的发病机制可能与种族无关。Objective To detect the expression of vascular endothelial growth factor receptors （VEGFR） kinase insert domain containing receptor （KDR） in the ectopic and entopic endometrial of Tibetan and Han nationalities patients with endometriosis （EM） and endometria. Methods 30 cases of ovarian endometrioma, and matched entopic endometria were biopsied from Tibetan patients with EM, another 30 cases of endometrium were biopsied from Han nationality women with EM. Reverse transcriptpolymease chain reaction （RT-PCR） analysis were utilized to examine KDR mRNA and levels in the endometrium. Results Among EM lesions, KDR mRNA expressed higher level than women without EM. The expressed of KDR mRNA has same level in the 2 groups. Conclusion The VEGFR KDR mRNA expressed the ectopic and entopic endometria of women with EM in Tibetan and Han nationality, showed the expression of KDR in endometria with might be related to the transfer and development of EM, and pronounced menstrual cycle-dependent expression in cycle endometria. But the express level was not related to the nationalities between 2 groups.

关 键 词：藏 汉族 血管内皮生长因子受体 子宫内膜异位症 正常子宫内膜 

分 类 号：R711.71[医药卫生—妇产科学]