缬沙坦对压力超负荷下心脏多聚二磷酸腺苷核糖合成酶活性的影响  

Effect of valsartan on action of poly(ADP-ribose) polymerase in pressure overload myocardium

作　　者：李小丽[1] 黄恺[1] 黄丹[1] 杨崇哲[1] 姚兰[1] 廖玉华[1] 

机构地区：[1]华中科技大学协和医院心内科

出　　处：《临床心血管病杂志》2008年第1期48-50,共3页Journal of Clinical Cardiology

基　　金：国家自然科学基金(No:30400175)

摘　　要：目的:观察缬沙坦对慢性压力超负荷下左心室心肌多聚二磷酸腺苷(ADP)核糖合成酶(PARP)活性、心脏形态及心功能的影响。方法:Wistar雄性大鼠34只随机分为假手术组(sham组)10只、腹主动脉缩窄组(AC组)12只、腹主动脉缩窄加缬沙坦干预结扎组(Val组)12只。术后24周行心脏超声和血流动力学检查,并取左心室心肌检测PARP活性。结果:与sham组比较,AC组PARP活性显著增强(P<0.01),左心室质量/体重(LVW/BW)显著升高(P<0.05),左心室射血分数显著降低(P<0.05);与AC组比较,Val组PARP活性显著减弱(P<0.01),LVW/BW显著降低(P<0.05),左心室射血分数明显升高(P<0.05)。结论:缬沙坦可抑制压力负荷下心室肌PARP过度激活,并减轻心室重构及心功能的损害。Objeetive：To study the effect of valsartan on PARP activition and myocardial remodeling in the left ventricle of the rat undergoing chronic pressure overload. Method： Thirty rats were randomly divided into 3 groups, as the sham operation group sham group, （n= 10）, the abdominal aorta constriction group （AC group, n =12）, and the AC＋valsartan group （Val group, n = 12）. Transthoracic echocardiography and homodynamic were performed. PARP activity of the model rats was detected. Result：Compared with the sham group, PARP activity and LVW/BW increased significantly in the AC group （P〈0.05）. Compared with the AC group, PARP activity and LVW/BW were decreased while ejection fraction of left ventricular increased significantly in the Val group （P〈0.05）. Conclusion：Valsartan could inhibit abnormal PARP activation and ventricular remodeling in rat undergoing chronic pressure overload.

关 键 词：缬沙坦 心室重构 多聚二磷酸腺苷核糖合成酶 

分 类 号：R587.2[医药卫生—内分泌]