促炎因子与抗炎因子在冠脉搭桥术围手术期的变化  

Comparison of Pro-and Anti-Inflammatory Cytokines in Perioperative Period of Coronary Artery Bypass Grafting

作　　者：王赞鑫[1] 邵杰[2] 李培军[1] 刘建实[1] 张金英[1] 魏民新[3] 杨洁[2] 

机构地区：[1]天津市胸科医院,300051 [2]天津医科大学基础医学院免疫教研室 [3]天津医科大学总医院

出　　处：《天津医药》2008年第2期87-89,共3页Tianjin Medical Journal

基　　金：天津市科技发展计划项目(项目编号:05YFSZSF02700);天津自然科学基金资助项目(项目编号:043613011);天津市卫生局重点基金项目(项目编号:04KY03)

摘　　要：目的:观察比较体外循环冠状动脉搭桥术(CABG)和非体外循环冠状动脉搭桥术(OPCAB)后炎症因子表达水平。方法:选取单纯冠脉搭桥手术患者57例。液相蛋白芯片系统(Liquichip)方法检测术前,术后1、4、24及72h的血浆中IL-6、IL-8、IL-10及TNF-α的表达水平,记录患者术后临床资料。结果:CABG组和OPCAB组术后炎症因子水平差异无统计学意义(均P>0.05)。2组术后IL-6、IL-8、IL-10水平均较术前有明显升高,术后1h达高峰(P<0.05),术后72h水平仍高于术前(P<0.05)。TNF-α水平术前术后差异无统计学意义(P>0.05)。结论:2组患者术后炎症因子水平与术前相比有明显的升高;CABG和OPCAB术后炎症因子水平差异无统计学意义。Objective： To observe and compare the perioperafive changes of IL-6, IL-8, IL-10 and TNF-α in coronary artery bypass grafting with and without eardiopulmonary bypass （CPB）. Methods： Blood samples were obtained from 57 patients before and 1,4,24,72 h after coronary artery bypass grafting （CABG）. The expressions of IL-6, IL-8, IL-10 and TNF-α were measured by Liquiehip assay. Other clinical data were recorded throughout the perioperative period. Results： There was no significant difference of eytokine＇ s level between CABG group and off-pump CABG（ OPCAB ） group. Levels of IL-6, IL-8 and IL-10 were increased lh after cardiac surgery （P 〈 0.05 ） and were still higher than those in preoperative at 72 h （P〈 0.05 ）. There were no change in levels of TNF-α before and after surgery （P〉 0.05 ）. Conclusion： Pro- and antiinflammatory eytokines were increased after surgery. There was no difference in inflammatory response between CABG and OPCAB.

关 键 词：白细胞介素类 冠状动脉分流术 体外循环 肿瘤坏死因子类 

分 类 号：R654.2[医药卫生—外科学] R563.8[医药卫生—临床医学]