非体外循环冠状动脉搭桥术后心肌损伤与炎症因子的关系  

The Relationship between Myocardium Injury and Cytokine after Off-Pump Coronary Artery Bypass Grafting

作　　者：简锴陶[1] 郭德和[1] 张凯[2] 魏民新[3] 

机构地区：[1]宁夏医学院,750004 [2]天津市胸科医院 [3]天津医科大学总医院

出　　处：《天津医药》2008年第2期93-95,共3页Tianjin Medical Journal

基　　金：天津市科技发展计划项目(项目编号:05YFSZSF02700)

摘　　要：目的:探讨非体外循环冠状动脉搭桥术(OPCABG)后心肌损伤与炎症因子的关系。方法:根据患者术后24h肌钙蛋白(ITnI)水平分为2组,TnI<0.16μg/L者为A组,TnI≥0.16μg/L者为B组。集中通过液相芯片技术同期检测术前及术后1、4、24、72h细胞因子白细胞介素(IL)-6、IL-8和IL-10的表达水平。结果:2组患者术后1hIL-6、IL-8、IL-10水平达高峰,(IL-6+IL-8)/IL-10于术后24h达到高峰。2组组内(IL-6+IL-8)/IL-10水平各时间点比较差异有统计学意义(P<0.01),而组间比较差异无统计学意义(P>0.05),组内各时间点与处理分组的交互作用差异无统计学意义(P>0.05)。结论:OPCABG伴有炎症反应过程,可导致术后炎症因子水平的变化,(IL-6+IL-8)/IL-10水平与术后24h时心肌损伤状况无关。Objective： To study the relationship between myocardium injury and cytokine after off-pump coronary artery bypass grafting. Methods： All patients were divided into two groups according to TnI 24 h after OPCABG. TnI〈0.16 μg/L was group A and TnI ≥0.16 μg/L was group B. Serum samples from vein were collected for measurement of IL-6, IL-8 and IL-10 before operation and 1,4,24 and 72 hours after operation respectively by liquichip measurement system. Results： The levels of IL-6,IL-8 and IL-10 in two groups were at the peak value 1 hour after the operation ,and （IL-6＋IL- 8 ）/IL-10 was at the peak value 24 hours after the operation. There were significant differences of the levels of （IL-6＋IL-8）/ IL-10 at different time points within the group （P 〈 0.01 ）. There was no significant difference of （IL-6＋IL-8）/IL-10 between groups （P 〉 0.05 ）. There was no significant difference of interaction between groups （P 〉 0.05 ）. Conclusion： The operation of off-pump coronary artery bypass grafting can raise inflammatory reaction and cause the changes of inflammatory cytokines. There is no relationship between the level of （IL-6＋IL-8）/IL-10 and the injury of myocardium 24 hours after the operation.

关 键 词：冠状动脉旁路移植术 非体外循环 白细胞介素类 心肌 炎症 

分 类 号：R654.2[医药卫生—外科学] R364.5[医药卫生—临床医学]