消瘀止痛气雾剂的稳定性考察及有效期预测  

Study on Stability of Xiaoyuzhitong Aerosol and Prediction of its Expiry Term

作　　者：叶盛英[1] 高文远[1] 杨本明[2] 杜欣[2] 

机构地区：[1]天津大学药物科学与技术学院,天津300072 [2]解放军第254医院药剂科

出　　处：《中国药师》2008年第2期129-130,共2页China Pharmacist

基　　金：全军青年学者基金(项目编号06Q017)

摘　　要：目的:考察消瘀止痛气雾剂的稳定性,并预测其有效期。方法:以高效液相法测定消瘀止痛气雾剂中主成分羟基红花黄色素A的含量,采用初均速法对其有效期进行预测。结果:羟基红花黄色素A进样量在0.3969μg～2.1168μg范围内与峰面积线性关系良好(r=0.9996),平均回收率为98.43%,RSD为1.81%(n=6)。该气雾剂稳定性好,室温25℃下有效期为2年。结论:初匀速法预测消瘀止痛气雾剂有效期简便、迅速。Objective： To study stability of Xiaoyuzhitong aerosol at 25 ℃ and to predict its expiry term. Method： The content of Hydroxyl safflor yellow A in Xiaoyuzhitong aerosol was determined by HPLC . Prediction of expiry was conducted by initial average rate methods. Result： The linear range was from 0. 396 9 to 2. 1168 μg （r =0.999 6）. The average recovery （n =6） was 98.43% and RSD was 1.81%. Stability of Xiaoyuzhitong aerosol is good, expiry of term predicted at 25℃ is 2 years. Conclusion： Initial average rate method is convenient and rapid.

关 键 词：消瘀止痛气雾剂 羟基红花黄色素A 高效液相法 初均速法 稳定性 

分 类 号：R927.11[医药卫生—药学]