2型糖尿病患者外周血白细胞计数与尿白蛋白相关性的研究  

The relation of peripheral leukocyte counts with urinary albumin in patients with type 2 diabetes

作　　者：高璐[1] 于德民[1] 

机构地区：[1]天津医科大学代谢病医院,300070

出　　处：《中国糖尿病杂志》2008年第1期12-14,共3页Chinese Journal of Diabetes

摘　　要：目的探讨2型糖尿病(T2DM)患者外周血白细胞(WBC)总数和分类计数与尿白蛋白(UAlb)的相关性。方法将564名T2DM患者根据尿白蛋白排泄率(UAER)进行分组。采用多元相关分析和logistic分析对年龄、病程、体质指数、血糖、血压、血脂、吸烟史等因素进行分析,以评价WBC计数对UAER的影响。结果随着UAER的增加,WBC总数和中性粒细胞、单核细胞、嗜酸和嗜碱性粒细胞数升高,而淋巴细胞数下降。在调整了年龄、性别、病程等危险因素后,这种差异仍然存在。结论在T2DM患者中,处于正常范围的WBC总数和分类细胞数与UAlb相关。Objective To investigate the relation of peripheral leukocyte total and its differential counts with urinary albumin（ UA1b） in patients with type 2 diabetes. Methods The 564 subjects with type 2 diabetes were stratified according to UAER levels. The total and differential leukocyte counts of peripheral blood were measured. Demographic and potential metabolic confounding factors were analyzed with multiple correlation and logistic regressions to evaluate the effects of leukocyte counts on UAER. Results With the increase of UAER, the peripheral total leukocyte, neutrophil, monocyte, eosinophil and hasophil counts increased. In contrast, the lymphocyte count decreased. The differences persisted even after adjusting the influence of age, sex, duration of diabetes and other known risk factors. Conclusions Our study shows that peripheral leukocyte counts, even within the normal range, are related with UA1b in subjects with type 2 diabetes in a dose-dependent manner.

关 键 词：白细胞 2型糖尿病 尿白蛋白 

分 类 号：R587.1[医药卫生—内分泌]