冰片对川芎嗪经鼻腔吸收入脑的影响  

Influence of borneol on nasal absorption of Ligustrazinee

作　　者：刘煜德[1] 孙寒静[2] 李荣[1] 吴伟[1] 陈宏珪[1] 

机构地区：[1]广州中医药大学第一附属医院内科,广东广州510405 [2]暨南大学医学院第四附属医院广州市红十字会医院,广东广州510220

出　　处：《中国中药杂志》2008年第3期259-261,共3页China Journal of Chinese Materia Medica

基　　金：广东省卫生厅项目(K3B20024);广州中医药大学校级课题(JQ0203)

摘　　要：目的:探讨冰片对川芎嗪经鼻腔吸收入脑的影响。方法:大鼠随机分为芎冰喷雾剂组、川芎喷雾剂组、芎冰灌胃剂组。给药后分别于不同的时间点断头取全脑,匀浆后以气相色谱法测定脑组织中川芎嗪浓度。结果:与川芎喷雾剂组比较,芎冰喷雾剂组川芎嗪更迅速进入脑组织并达到峰浓度,其峰值也高于前者;与芎冰灌胃剂组相比,芎冰喷雾剂吸收迅速、分布迅速,消除迅速。结论:鼻腔给药是治疗缺血性脑血管机能不全急性期的一种速效途径;冰片提高了川芎嗪经鼻腔吸收入脑的速度,增加了脑组织中川芎嗪的吸收量。Objective： To evaluate the influence of borneol on nasal absorption enhancement of ligustrazine. Method： The rats were randomly divided into 3 groups： Xiongbing nasal spray group （group A）, Chuanxiong nasal spray group （group B） and Xiongbing group by decoction intragastric administration（ group C）. All the rats were decapitated at several time points after administration. The whole brains of rats were taken to homogenate and detected the concentrations of ligustrazine. Result： Compared with group B and C, group. A has its characteristics ： quick absorption, quick distribution and quick excretion of ligustrazine. Condusion： Nasal administration is a quick-acting way for ischemic cerebral vessel insufficientia. Borneol promoted nasal absorption of ligustrazine into brain.

关 键 词：冰片 川芎嗪 鼻腔给药 

分 类 号：R285[医药卫生—中药学]