天南星科有毒中药刺激性作用比较研究  

Study on irritation of calcium oxalate crystal in Araceae plants

作　　者：吴皓[1] 钟凌云[1] 

机构地区：[1]南京中医药大学中医药研究院,江苏南京210029

出　　处：《中国中药杂志》2008年第4期380-384,共5页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(30772785);国家十一五支撑计划项目(2006BAI09B06-10)

摘　　要：目的:研究天南星科具有刺激性毒性作用的部分中药中草酸钙针晶的刺激性作用。方法:采用家兔眼刺激实验方法,考察水半夏、白附子、天南星药材提取的草酸钙针晶的刺激性作用,并对各药材草酸钙针晶刺激性作用进行量效关系试验。结果:生水半夏、生白附子、生天南星中的草酸钙针晶具有强烈刺激性,各药材提取的针晶与各药材生品混悬液在针晶含量相同的条件下,对家兔的眼刺激性作用基本相同,同时针晶浓度与家兔眼刺激程度呈现确切的量效关系。结论:天南星科部分具有刺激性毒性作用的中药中所含的草酸钙针晶是其刺激性成分。Objective： To validate the irritation effects of calcium oxalate crystal in several herbal drugs which come from Araceae plants. Method： Compared the irritation of pure calcium oxalate crystals isolated from the raw rhizome of Typhonium flagelli-forme, T. giganteum and Arisaema erubescens and studied the quantity and inritating effect relationship of different concentration suspen-sions of needle-like calcium oxalate crystals by using the model of rabbits＇eyes. Result： Calcium oxalate crystals isolated from above three rau rhizome typhonium rhizome showed strong irritation effects on rabbits＇ eyes. Under the condition of same content of calcium oxalate crystals, there were no difference in irritation effect between the suspensions of raw medicinal materials and pure calcium oxalate crystals. The degree of irritation on rabbits＇eyes showed undoubted quantity and irritating effect relationship with the concentrations of Calcium oxalate crystel. Conclusion： Calcium oxalate crystal is the irritant component in some herbal drugs which come from Araceae plants.

关 键 词：天南星科 草酸钙针晶 刺激性作用 

分 类 号：R285[医药卫生—中药学]