雷公藤多苷对儿童复发性肾病Th1，Th2细胞因子影响的研究  

Effect of triptergium wilfordii polyglycosidium on content of Th1 and Th2 in child rcurrent nephrotic syndrome

作　　者：胡国华[1] 易著文[2] 王井和[3] 姚静婵[1] 

机构地区：[1]金华职业技术学院医学院,浙江金华321000 [2]中南大学湘雅二医院小儿肾脏病研究室,湖南长沙410011 [3]浙江省义乌市中心医院,浙江义乌322000

出　　处：《中国中药杂志》2008年第4期441-443,共3页China Journal of Chinese Materia Medica

摘　　要：目的:探讨雷公藤多苷对小儿复发性肾病(RNS)患者Th1/Th2细胞因子的影响。方法:分别设治疗组与健康组。治疗组31例用雷公藤多苷1 mg.kg-1.d-1,分3次口服,12周为1疗程。健康组未服任何药物。且在治疗前检测2组血IL-12,IL-2,TNF-,αIL-13,IL-6,IL-4浓度。疗程结束后再测上述细胞因子。结果:治疗组血中除IL-12外其余Th1/Th2细胞因子水平均比治疗前降低(P<0.01)。结论:雷公藤多苷对小儿RNS的Th1/Th2细胞因子(除IL-12外)均有抑制作用,这可能是治疗RNS的重要机制之一。Objective： To study the effect of triptergium wilfordii polyglycosidium on the content of Th1 and Th2 in the treat-ment child patients of rcurrent nephrotic syndrome. Method： Patients were randomized into treatment group and health group. Sixty-one patients in treatment group were treated with triptergium wilfordii polyglycosidium 1 mg·kg^-1·d^-1 orally tid for 12 weeks. How-ever, patients in health group was not treated with any drugs. Twelve weeks constituted one course of treatment and the content of IL-12, IL-2, TNF-α, IL-13, IL-6, IL-4 in peripheral blood was measured before and behind therapy. Result： In treatment group, the content of serum cytokines behind therapy was significantly lower than that before therapy, except for IL-12. Conclusion： Triptergium wilfordii polyglycosidium could reduce the cytokine level （ except for IL-12） of Thl and Th2, which could lead a therapeutic effect of in the child patients of RNS.

关 键 词：雷公藤多苷 复发性肾病(RNS) 细胞因子 

分 类 号：R272[医药卫生—中医儿科学]