家兔P300样电位与丘脑腹后外侧核及隔区内侧核关系的研究  

Relationship between P300 and Ventralis Posterolateralis Thalami Nucleous and Medial Septal Nucleous

作　　者：林杭[1] 吴宗耀[1] 

机构地区：[1]第三军医大学西南医院康复理疗科

出　　处：《中华物理医学杂志》1997年第2期102-104,共3页Chinese Journal of Physical Medicine and Rehabilitation

摘　　要：目的：研究家兔丘脑腹后外侧核（ＶＰＬ）及隔区内侧核（ＳＥＰ）与Ｐ３００样电位的关系。方法：在家兔颅骨内和ＶＰＬ及ＳＥＰ植入绝缘针电极，记录破坏ＶＰＬ和ＳＥＰ前后颅骨内、ＶＰＬ、ＳＰ的Ｐ３００样电位的变化。结果：破坏ＶＰＬ后头颅所记Ｐ３００样电位无变化。破坏ＳＥＰ后第一天，头颅所记Ｐ３００样电位无变化。第２～６天，头颅所记Ｐ３００样电位Ｐ２７０Ｎ３３０Ｐ４００的潜伏期逐日延长，波幅逐渐降低以至于消失。结论：丘脑腹后外侧核与Ｐ３００的发生毫无关系。ＳＥＰ不是Ｐ３００的起源，但是Ｐ３００电位的存在有赖于ＳＥＰ的完整。Ｐ３ａ的起源可能在ＳＥＰ胆碱能纤维投射的扣带回或嗅皮层。Objective: To search the neurological source of P300 like potential,the relationship between P300 like potential and the ventralis posterolaterolis thalami nucleous(VPL) and medical septal nucleous(SEP). Methods:Isolated needles were implanted into the skull,VPL,SEP. An oddball paradigm sound stimulus was adapted and P300 like potentials were recorded at 3 sites mentioned pre and post injuries of VPL and SEP. Results: There was no difference of P300 like potentials pre and post injuries of VPL. The first day after the lesion of SEP,the P300 like potentials changed little.From 2nd to 6th days,the latency of P270 N330 P400 prolonged,the amplitude decreased gradually,and disapeared eventually. Conclusion: VPL is not necessary for the rabbit P300 like potential as a generator. SEP is not the source of P300. But the existence of P300 depends upon the intact of SEP. The source of P300 might be located at the cingulate cortex or the olfactory cortex.

关 键 词：丘脑核 生理学 丘脑核损伤 电位测定法 兔 

分 类 号：R338.27[医药卫生—人体生理学] R651.15[医药卫生—基础医学]