二氧化硅粉尘作业工人肾功能损害的调查研究  

INVESTIGATION ON RENAL DYSFUNCTION OF WORKERS EXPOSED TO SILICA DUST

作　　者：徐成伟[1] 许顺良 周勇 戴秀莲 孙少秋[3] 

机构地区：[1]山东医科大学第二附属医院 [2]山东省劳动卫生职业病防治研究所 [3]济南市职业病防治院

出　　处：《工业卫生与职业病》1997年第4期205-209,共5页Industrial Health and Occupational Diseases

摘　　要：对153名二氧化硅粉尘作业工人（接尘组）和84名年龄相当但不接尘及其它毒物者（对照组）肾功能进行调查。结果发现接尘工人尿NAG活性及尿α1－MG、β2-MG、A1b含量较对照组显著升高，且随接尘工龄延长而明显升高，呈剂量-反应关系。若以超过对照组95％单侧上限值为阳性标难，则尿α1－MG、β2-MG、A1b、NAG阳性率增高有显著意义，且尿酶与尿蛋白各指标之间呈正相关关系。表明长期接触含游离二氧化硅的粉尘除可引起呼吸系统功能损害外，尚可导致肾小球和肾小管的混合性损伤。提示尿α1－MG、β2-MG、A1b、NAG测定可作为矽尘所致慢性肾损害的敏感检测指标。The relationship between renal alteration and silica exposure was observed. 153 silica exposedworkers and 84 unexposed healthy subjects as controls were investigated. The results showed thatthe levels of urinary α1-microglobulin (α1-MG), β2-microglobulin (β2-MG),albumin (A1b) and Nacetyl - β-D-glucosaminida se (NAG) in the exposed group were significantly higher than those of thecontrols. They increased progressively with the increase of the working-age. If the value>95% ofthat found in the controls was taken as the criterion for significance,the abnormal prevalence ofurinary α1-MG, β2-MG , A1b, NAG in the exposed group was significantly increased. The relationship between urinary NAG and urinary α1-MG, β2-MG, A1b, showed positive correlation(P<0.001). It is suggested that the silica dust not only could lead to lung damage,but also mightcause a mixed proximal tubular and glomerular dysfunction, Changes of urinary α1-MG,β2-MG,Alb,NAG might be taken as valuable indices for early detection of chronic subclinical renal dysfunctionin silica exposed workers.

关 键 词：二氧化硅 粉尘 尿酶 尿微量蛋白 肾损害 

分 类 号：R135.2[医药卫生—劳动卫生]