三硝基甲苯作业工人和HBsAg阳性者血清磷酸化酶a活性的变化  

A activities in serum of TNT exposed workers in comparison with positive Changes of phosphorylase

作　　者：崔京伟[1] 常元勋[1] 江泉观[1] 李观钦 孙灵鹤 刘文献 赵鸿 刘淑坤 杨振中 刘海喜 

机构地区：[1]北京医科大学劳动卫生教研室 [2]河南省平顶山煤炭卫生学校 [3]河南省职业病防治所

出　　处：《职业医学》1997年第2期1-2,共2页China Occupational Medicine

摘　　要：对河南某化工厂ＴＮＴ作业工人劳动卫生学调查结果发现，车间空气中ＴＮＴ浓度多数均超过国家最高允许浓度（ＭＡＣ＝１ｍｇ／ｍ３），工人皮肤污染较严重。血清磷酸化酶ａ活性测定结果表明，ＴＮＴ接触组明显高于对照组，而ＨＢｓＡｇ阳性组与对照组比较无明显差异。推测ＴＮＴ与ＨＢｓＡｇ阳性肝损伤机理可能不同，可考虑以磷酸化酶ａ活性的变化作为评价ＴＮＴ早期肝损伤的指标。The results of occupational investigations in the plant operating trinitrotoluene(TNT)in He Nan province showed that the TNT concentrations in air of the workplaces mostly exceeded the national maximum allowable concentration(MAC=1mg/m 3)and the skin of the exposed workers appeared to be severely contaminated.The activity of serum GPT and positive rate of HBsAg in both exposed and control group showed no significant differences.However,serum phosphorylase A activities in TNT exposed workers increased significantly.It suggested that changes of serum phosphorylase A activities might serve as an index for detecting early liver damage induced by TNT.

关 键 词：三硝基甲基 血清 磷酸化酶A 病毒性肝炎 

分 类 号：R134.4[医药卫生—劳动卫生] R512.604[医药卫生—公共卫生与预防医学]