补肾和健脾对免疫系统不同作用方式的研究  

Study of Different Pattern of Immuno-Modulatory Mechanism by Tonifying Kidney and Invigorating Spleen

作　　者：沈自尹[1] 蔡定芳[1] 张玲娟[1] 钟历勇[1] 陈晓红[1] 

机构地区：[1]上海医科大学华山医院,南京铁道医学院

出　　处：《中国中西医结合杂志》1997年第6期351-353,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金

摘　　要：目的：探讨补肾药对免疫系统的作用方式。方法：用３类复方对皮质酮大鼠分别在７天与１４天实验里，进行对神经内分泌及免疫系统不同作用方式的研究。结果：无论７天或１４天，健脾组的免疫系统均得到保护，而神经内分泌系统却未有明显作用，说明健脾药是对免疫系统的直接作用；补肾组虽７天实验尚未见对各系统有何影响，至１４天实验才显示对神经内分泌免疫系统的全面作用。结论：补肾药是先作用于神经内分泌系统，而后才影响于免疫系统，亦即是作用于神经内分泌免疫网络的下行通路。To observe the acting pattern on the immune system by tonifying the Kidney (TK). Methods:Three composite recipes were used on the 7-and 14-day corticosterone rat model to study the effect of recipes on the different pattern of immuno-modulatory and neuroendocrinological systems. Results: The immune system of invigorate the Spleen (IS)group was well protected in either 7-day or 14-day experiment,without any effect of IS recipe acting on the neuroendocrine system,it suggested that IS recipe might have direct action on immune system,while TK group with no effect on neuroendocrine-immune (NEI)system in 7-day experiment, but showed the remarkable protective effect of the whole NEI system until 14-day experiment. Conclusion: The results indicated that TK recipe is acting on the neuro endocime system first, and then influence the immune system. It means that the action was through down pathway of NEI network.

关 键 词：补肾 健脾 右归饮 

分 类 号：R977.9[医药卫生—药品]