Natural Compound Curcumin Corrects the Gating Defect of G551DMutant Cystic Fibrosis Transmembrane Conductance Regulator  

作　　者：HAO Li-ming LIU Xin XU Li-na ZHU Na LIN Sen HOU Shu-guang ZHOU Na SHI De-cheng SHANG De-jing MA Tong-hui YANG Hong 

机构地区：[1]Membrane Channel Research Laboratory, Northeast Normal University, Changchun 130024, P. R. China [2]China-Japan Union Hospital, Jilin University, Changchun 130033, P. R. China [3]School of Basic Medicine, Jilin University, Changchun 130021, P. R. China [4]College of Life Sciences, Liaoning Normal University, Dalian 116029, P. R.China

出　　处：《Chemical Research in Chinese Universities》2008年第1期92-95,共4页高等学校化学研究（英文版）

基　　金：National Natural Science Fund for Distinguished Young Scholars(No.30325011);National Natural Science Foundation of China(Nos.30470405, 30570864, 30670477);Distinguished Young Scholars Fund of Jilin Province (No.20030112) ;Excellent Young Teachers Program of Ministry of Education, China

摘　　要：In the present study, we identified the natural compound curcumin to be an effective G551D-CFTR activator by cell-based fluorescent assay and electrophysiological measurement. We demonstrated that curcumin can restore the impaired chloride conductance of G551D mutant CFTR. The activity is rapid, reversible, and cAMP-dependent. Our study identified a new natural lead compound for the pharmacological therapy of cystic fibrosis caused by G551D mutation of CFTR.In the present study, we identified the natural compound curcumin to be an effective G551D-CFTR activator by cell-based fluorescent assay and electrophysiological measurement. We demonstrated that curcumin can restore the impaired chloride conductance of G551D mutant CFTR. The activity is rapid, reversible, and cAMP-dependent. Our study identified a new natural lead compound for the pharmacological therapy of cystic fibrosis caused by G551D mutation of CFTR.

关 键 词：Cystic fibrosis CFTR MUTATION Natural compound ACTIVATOR 

分 类 号：R977.15[医药卫生—药品]