辅助表面活性剂对微乳相行为的影响  

Effect of Co-surfactant on Phase Behavior of Microemulsions

作　　者：姚静[1] 周建平[1] 平其能[1] 陈亮[1] 卢韵[1] 

机构地区：[1]中国药科大学药剂教研室,南京210009

出　　处：《中国现代应用药学》2008年第1期39-43,共5页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的考察辅助表面活性剂对微乳相行为的影响，指导微乳制剂的研究和开发。方法采用滴水法制备微乳相图，以O／W微乳区面积和最大载油量为指标，考察辅助表面活性剂种类和性质对微乳形成的影响。结果短链醇（2～3个碳）的微乳区显著大于长链醇（大于5个碳），而CLogP在1附近的正丁醇和苯甲醇辅助乳化效果亦较好；弱碱性助表（酰胺类）可促进采用弱酸性油相（如油酸）的微乳形成。结论与油水两相间均有良好互溶性的助表更有利于微乳的形成。OBJECTIVE To study the effect of the type and characterization of co-surfactant on the phase behavior of the microemulsions. METHODS The pseudo-ternary phase diagrams were constructed by the water titration method, and the effect of the cosurfactant on the phase diagram was also investigated. The region of microemulsion and the maximum oil-loaded content were used as the evaluating index. RESULTS The regions of the oil-in-water （o/w） microemulsion of the systems with short-chain alcohol （2-3 C chains） as the co-surfactant are much larger than those with long-chain alcohol （ 〉 5 C chains）. Both n-butanol and phenylmethanol were suitable for preparing microemulsions owing to their CLog P （ near 1 ） although their carbon chains are longer. The amides with the weak alkalinity can facilitate the forming of the microemulsions using oleic acid as the oil phase. CONCLUSION A better co-surfactant should have the appropriate partition coefficient between oil and water,which may facilitate the forming of the microemulsions.

关 键 词：辅助表面活性剂 微乳 伪三元相图 

分 类 号：R944.1[医药卫生—药剂学]