厄他培南治疗呼吸机相关性肺炎的临床疗效  

Clinical Effect of Ertapenem on Ventilator-associated Pneumonia

作　　者：应小飞[1] 何伟珍[1] 田伟强[1] 朱虹云[1] 

机构地区：[1]浙江省丽水市中心医院,浙江丽水323000

出　　处：《中国现代应用药学》2008年第1期76-78,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的比较厄他培南与亚胺培南/西司他丁治疗呼吸机相关性肺炎的有效性和安全性。方法采用随机对照设计,观察厄他培南与亚胺培南/西司他丁治疗60例呼吸机相关性肺炎的临床疗效和不良反应。结果厄他培南组30例,治疗有效率为90.0%,细菌清除率为83.3%;亚胺培南/西司他丁组30例,治疗有效率为86.7%,细菌清除率为82.1%;两组间差异无显著性;两组不良反应发生率均为6.7%。结论厄他培南治疗呼吸机相关性肺炎与亚胺培南/西司他丁相当,安全高效。OBJECTIVE To compare the effect and safety between ertapenem and imipenem on the ventilator-associated pneumonia. METHODS Trabant comparative study was conducted to compare the clinical effect and safety of ertapenem versus imipenem in the treatment of 60 cases of ventilator-associated pneumonia. RESULTS Thirty patients of ventilator-associated pneumonia were enrolled into ertapenem group with an effective rate of 90.0% and bacteriological eradication rate of 83. 3%. On the other hand, thirty patients of ventilator-associated pneumonia were enrolled into imipenem group with an effective rate of 86.7% and bacteriological eradication rate of 82.1%. There was no significant difference between two groups. The rate of adverse reaction for both ertapenem and imipenem was 6.7%. CONCLUSION Ertapenem is safe and effective to ventilator-associated pneumonia.

关 键 词：厄他培南 亚胺培南/西司他丁 呼吸机相关性肺炎 治疗 

分 类 号：R916.695[医药卫生—药学]