慢性特发性心房颤动患者的血栓前状态  

作　　者：黄瑛[1] 周南芳[1] 刘志华[2] 

机构地区：[1]浦东新区人民医院心内科,上海201200 [2]苏州大学附属第一医院心内科

出　　处：《继续医学教育》2007年第34期67-69,共3页Continuing Medical Education

摘　　要：目的:探讨慢性特发性心房颤动患者的血栓前状态及其临床意义。方法:测定正常组30例、慢性特发性房颤组30例、慢性非瓣膜性器质性心脏病房颤组30例的血浆血小板颗粒膜蛋白140(GMP140)、血管性假性血友病因子(vWF)、纤维蛋白原(Fg)的含量进行比较。结果:(1)慢性特发性房颤组和慢性非瓣膜性器质性心脏病房颤组GMP140、vWF及Fg均明显高于正常对照组。(2)慢性特发性房颤组GMP140、vWF及Fg却低于慢性非瓣膜性器质性心脏病房颤组(P<0.05)。结论:慢性特发性房颤患者和慢性非瓣膜性器质性心脏病房颤患者一样具有血栓前状态,血栓前状态由房颤本身所致,慢性特发性房颤患者亦需积极的抗栓治疗。Objective, To study the change of prothrombotic state in chronic idiopathic atrial fibrillation. Method： Plasma levels of Granule membrane protein 140 （GMP140）. von Willebrand factor （vWF） and fibrinogen （Fg） were measured in plasma from 30 patients with idiopathic atrial fibrillation, 30 patients with chronic organic heart disease and 30 normal peoples. Results： The levels of the plasma GMP140. VWF. fibrinogen of chronic idiopathic atrial fibrillation were higher than those of normal people, but lower than those of organic heart disease. Conclusion; The results confirmed that the patients with chronic idiopathic atrial fibrillation had the same prothrombotic state as those of organic heart disease. Prothrombotic state resulted form atrial fibrillation itself. The patients with chronic idiopathic atrial fibrillation must accept the treatment of antithrombotic.

关 键 词：慢性特发性心房颤动 血小板Α颗粒膜蛋白140 血管性假性血友病因子 纤维蛋白原 血栓前状态 

分 类 号：R541.7[医药卫生—心血管疾病]