安徽某地区既往有偿供血人群HIV-1感染者疾病进展与临床表现的相关性研究  

Correlation between clinical manifestations and disease progression among HIV-1 infected former blood donors in Anhui,China

作　　者：韩丽凤[1] 徐臣[2] 徐建青[1] 苏斌[3] 阮玉华[1] 丁心平[2] 冯毅[1] 高冰 谷永彬[5] 彭虹[1] 袁霖[1] 邵一鸣 

机构地区：[1]中国疾病预防控制中心性病艾滋病预防控制中心,北京100050 [2]阜阳市疾病预防控制中心,安徽阜阳236030 [3]安徽省疾病预防控制中心,合肥230061 [4]颖州区疾病预防控制中心,安徽阜阳236000 [5]阜南县疾病预防控制中心,安徽阜南236300

出　　处：《中国艾滋病性病》2008年第1期5-8,共4页Chinese Journal of Aids & STD

基　　金：美国国立卫生研究院传染病与变态反应研究所CIPRA项目资助(CIPRA,U19AI51915)

摘　　要：目的了解既往有偿供血人群艾滋病病毒Ⅰ型（HIV-1）感染者的疾病进展状况，分析疾病进展过程中免疫缺损与临床表现间的关系。方法选择安徽某地区未服用抗病毒药的HIV-1阳性既往供血员，通过横断面调查，收集人口学、近期症状／体征、血液学及CD4^＋细胞计数。结果294名研究对象中，49人的CD4^＋细胞计数≥500个/μl，83人在350--499个/μl，85人在200～349个/μl，77人〈200个/μl。研究对象经历了各类临床表现，最常见的症状是经常性疲乏（35．4％），体重减轻（24．5％），食欲不振（22．1％），出现体重减轻、发热、皮疹、口腔白斑者的cm；细胞计数的中位数分别为225、245、214、75，明显低于无上述症状者；最常见的体征是皮肤（12．9％）和口腔黏膜（7．8％）的异常表现，CD；细胞计数的中位数分别为160、216，显著低于未出现者；最常见的血液学异常是中性粒细胞（47．2％）、嗜酸性粒细胞（34．5％）及血细胞压积（23．5％）减少，出现贫血，血细胞压积，单核细胞、淋巴细胞、中性粒细胞减少的CD；细胞计数的中位数分别为172、189、195、119、276，明显低于未出现者。结论该人群在感染HIV-1的10余年后，处于免疫缺陷期，免疫缺陷早、中、晚期的比例分别为16．7％、28．2％、28．9％及26．2％。口腔白斑、皮疹、体重减轻、长期发热、贫血、血细胞压积、淋巴细胞减少的出现，与免疫缺陷程度密切相关。Objective To understand infection status among HIV-1 positive former blood donors and to study the correlation between their clinical manifestations and progression of immune deficiency.Methods ART naive HIV-1 positive former blood donors were enrolled, and demographic, clinical and hematological data, as well as CD4^＋ T cell counts were collected among them through a cross sectional study. Results Of the 294 study subjects,49 had CD4^＋ T cell counts ≥500 cells/μl,83- between 350 and 499 cells/μl, 85- between 200 and 349 cells/μl and 77- 〈 200 cell/μl. Different clinical symptoms were present among the subjects, and the most frequent complaints were; fatigue （35.4%）, weight loss （24.5 % ）and poor appetite（22.1% ）. In those complaining of weight loss, fever, dermatitis and oral leukoplakla the median CD4^＋ T cell counts were 225,245,214 and 75, respectively, significantly lower than in those without such com- plaints. The most frequent abnormal signs were observed on skin（ 12.9 % ）and mucous membrane of mouth（7.8% ）, and the median CD4＋ T cell counts in the subjects with these signs were 160 and 216, respectively. The most frequent hematological abnormalities were decreasing neutrophils （47.2%）, eosinophils （34.5%） and hematocrits （23.5%） ,and the median CD4^＋ T cell counts in the subjects with decreasing hemoglobins, hematocrits, monocytes, lymphocytes and neutrophils were 172,189,195, 119 and 276 ,respectively. Subjects with the above clinical manifestations or abnormal laboratory parameters had significantly lower CD2 T cell counts than those without such observations.Conclusion After having contracted HIV-1 infection for more than 10 years, the subjects who were free from immune deficiency, and who were at stages of early, middle and late immune deficiency accounted for 16.7%, 28.2%, 28.9% and 26.2%, respectively.Oral leukoplakia, dermatesis, weight loss, fever and decreasing hemoglobins, hematocrits and lymphocytes were closely associated with the disease prcg

关 键 词：既往供血员 艾滋病病毒感染 疾病进展 临床表现 

分 类 号：R373.9[医药卫生—病原生物学]