轮状病毒全身性感染一例分析  

A case report of systemic infection caused by rotavirus

作　　者：姚英民[1] 赵枫[1] 吴建春[1] 邱红明[1] 谢孟坤[1] 

机构地区：[1]第一军医大学南方医院儿科

出　　处：《中华儿科杂志》1997年第7期356-357,共2页Chinese Journal of Pediatrics

摘　　要：为了探讨轮状病毒（ＲＶ）肠道外感染问题，对１９９６年１月初广州地区ＲＶ腹泻高峰期间死亡１例婴儿做了尸体解剖，同时采用反转录聚合酶链反应（ＲＴ－ＰＣＲ）技术对有关组织和体液检测了ＲＶ抗原。结果显示，光镜下，患儿肠组织呈典型ＲＶ胃肠炎改变，肺和脑组织显示间质性肺炎、脑膜脑炎提示病毒感染所致，在脑脊液、腹水、肺组织和粪便中均可检出ＲＶ，血与胆汁中未检出。提示患儿在疾病早期可能存在一过性病毒血症，导致ＲＶ全身播散。ＲＶ是否对呼吸系统与中枢神经系统亦为易受侵犯的脏器与组织。To study the extaintestinal infection caused by rotavirus (RV), the authors performed autopsy on a case died of RV gastroenteritis and reverse transcription polymeras chain reaction for RV RNA detection. The results showed that the histopathogical changes of viral infection were observed in the intestine, lung and brain of the infant. Human group A rotavirus RNA was detected in pulmonary tissues, cerebrospinal fluid and ascites of the patient, but it couldn′t be detected in the blood and bile. The results suggested that RV might cause transient viremia and result in RV general dissemination.

关 键 词：轮状病毒感染 组织分布 腹泻 婴幼儿 全身感染 

分 类 号：R512.5[医药卫生—内科学]