在光动力疗法中应用的量子点  

Quantum Dots Applied in Photodynamic Therapy

作　　者：刘庆华[1] 余亮[1] 熊建文[1] 

机构地区：[1]华南师范大学物理与电信工程学院,广东广州510006

出　　处：《激光生物学报》2008年第1期138-142,F0003,共6页Acta Laser Biology Sinica

基　　金：广东省自然科学基金项目(7005845)

摘　　要：概述了现存的主要量子点的构成及其特点,阐述了量子点的性质主要由量子点的成分、结构、包覆和尺寸所决定。并重点讨论量子点在光动力疗法中,量子点直接代替传统光敏剂、量子点的荧光共振能量转移、量子点作为宽禁带半导体材料TiO2的敏化剂等三种不同应用中,对量子点的要求,通过讨论指出由于其特性,量子点将在光动力疗法中得到更广泛的应用,也对在光动力疗法中应用的量子点的毒性及其他可能产生的问题提出了展望。The composition and characterristics of the existing Quantum dots are stated in this paper. Properties of quantum dots are determined by the component, structure, outer coating and size of QDs. The main idea of this paper is to discuss the requirements of QDs in three different ways of application in the process of photodynamic therapy. The three ways contain the escence substitution for the traditional photosensitizer, the fluorescence resonance energy transfer （FRET） of QDs and the sensitizer of semiconductor material TiO2. The quantum dots will be applied more widely in the photodynamic therapy because of their properties. An outlook for QDs＇ toxicity and other new problems in the photodynamic therapy is also presented.

关 键 词：光动力疗法 量子点 光敏剂 荧光共振能量转移 

分 类 号：R454.2[医药卫生—治疗学]