葛根异黄酮的抗氧化作用  

Antioxidation of Pueraria lobata Isoflavones (PLIs)

作　　者：张光成[1] 方思鸣[1] 

机构地区：[1]同济医科大学,武汉430030

出　　处：《中药材》1997年第7期358-360,共3页Journal of Chinese Medicinal Materials

基　　金：国家自然科学基金

摘　　要：本文通过葛根异黄酮对动物组织中的脂质过氧化产物LPO含量和超氧化物歧化酶SOD活性研究探讨了葛根异黄酮类化合物的抗自由基作用。体外实验表明,葛根异黄酮10～1000μg/ml可明显抑制小鼠肝,肾组织及大白兔脑组织匀浆在振荡温育条件下引起的脂质过氧化产物丙二醛(MDA)的升高,并呈剂量效应关系。体内实验表明,大白兔经液氮冷冻致脑伤成脑水肿后,葛根异黄酮对降低血、脑组织中LPO含量有明显作用,而且对提高血、脑组织中SOD活性有极显著作用。Isoflavones are isolated from Pueraria lobata. By studyign Pueraria lobata isoflavones (PLIs)on lipid peroxide (LPO) and superoxide dismutase (SOD) in animal tissue, this paper suggests that PLIs is an effective an-tioxidant. The results in vitro show that PLIs can inhibit signficantly the content of LPO. The highest inhibition rate are found to be 79. 7%, 84. 7% , and 86. 6% in liver, kidney of mice and brain of rabbit respectively. By cold induced brain injury with chalcone, the content of LPO and activity of SOD in animal blood and brain are changed. When animals are injected with PLIs, the result indicates that the PLIs can reduce significantly the content of LPO and enhance the activity of SOD in animal blood and brain, in a dose-dependent relationship.

关 键 词：葛根异黄酮 葛根 抗氧化作用 中药药理学 

分 类 号：R285.5[医药卫生—中药学]