来氟米特对BXSB狼疮鼠免疫状况的影响  

Influence of leflunmide on the immune status of BXSB lupus mice

作　　者：李智铭[1] 徐世正[2] 章泳[2] 童汉云[2] 

机构地区：[1]浙江省温州医学院附属第一医院皮肤科,325000 [2]武汉大学人民医院皮肤科,430060

出　　处：《中国麻风皮肤病杂志》2008年第1期6-8,共3页China Journal of Leprosy and Skin Diseases

摘　　要：目的:观察来氟米特对BXSB小鼠免疫状况的影响。方法:48只3月龄的雄性BXSB小鼠分为4组,治疗前后测定24h尿蛋白;治疗后检测血清抗dsDNA抗体以及肾脏免疫复合物。结果:治疗后,来氟米特组的尿蛋白、抗dsDNA抗体明显低于地塞米松和生理盐水组(P<0.01),也低于环磷酰胺组,但其组间差异无统计学意义(P>0.05);来氟米特组的肾脏免疫复合物低于其他治疗组(P<0.05或P<0.01)。与生理盐水组相比,来氟米特组小鼠的生存期明显延长(χ2=4.56,P<0.05)。结论:来氟米特可显著改善BXSB小鼠的免疫状况,能延缓BXSB狼疮鼠的疾病进程。Objective： To investigate the effect of leflunmide on the immune status of BXSB mice. Methods： Forty -eight 3- month-old BXSB lupus mice were divided into four groups （including leflunmide group, cyclophosphamide group, dexamethasone group and saline group）. The 24- hour urine proteins were determined before treatment. After treatment, the urine protein, anti- dsDNA and irranune complex in renal glomeruli were measured. Results： After treatment, the urine protein, anti - dsDNA antibodies levels in leflunmide group were significantly lower than those in dexamethasone and saline groups （ P 〈 0.01）. Immune complex in renal glomeruli in leflunmide group were significantly lower than those in other groups （ P 〈0.05 or P 〈 0.01）. Compared to saline group, leflunmide prolonged life period of BXSB mice （ x^2 = 4.56, P 〈 0.05）. Conclusion： The leflunmide can improve immune status of BXSB mice and defer the disease progression.

关 键 词：来氟米特 治疗 系统性红斑狼疮 BXSB小鼠 

分 类 号：R593.241[医药卫生—内科学]