细胞免疫应答与丙型肝炎病毒感染慢性化  

Cellular immune response and the chronicity of hepatitis C virus infection

作　　者：李新华[1] 张欣欣[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院感染科,200025

出　　处：《国际流行病学传染病学杂志》2008年第1期41-44,共4页International Journal of Epidemiology and Infectious Disease

摘　　要：HCV感染是导致慢性肝脏疾病的主要病因之一。HCV在感染个体中表现出极高频率的病毒持续性，具有逃逸免疫识别和破坏宿主免疫应答的能力。目前研究认为，细胞免疫对HCV的清除起重要作用，而HCV慢性感染者有不同程度的细胞免疫应答异常。此文对细胞免疫应答与HCV感染及慢性化的可能机制作了综述。HCV infection is one of the major causes of chronic liver diseases. Easily escaping from immunologic recognition and nullifying the host immunologic response, it has high frequency of persistence. Recent studies show that the cellular immune plays an important role in the elimination of HCV, and there is different immune responsive impaired in chronic hepatitis C patients. In this review, we discuss the cellular immune response and its correlation with the chronicity of HCV infection.

关 键 词：肝炎病毒 丙型 细胞免疫 慢性化 

分 类 号：R51[医药卫生—内科学]