全身照射对造血干细胞移植后造血系统重建的临床分析  

Clinical analysis of hematopoiesis reconstruction after total body irradiation in hematopoietic stem cell transplantation

作　　者：房彤[1] 高宏[1] 孙保锦[1] 陈力[1] 

机构地区：[1]北京世纪坛医院放疗科,100038

出　　处：《中华放射医学与防护杂志》2008年第1期66-68,共3页Chinese Journal of Radiological Medicine and Protection

摘　　要：目的分析比较全身照射对自体和异体造血干细胞移植后造血重建状况的影响。方法对70例自体和异体造血干细胞患者移植后造血系统重建状况进行动态观察及分析。结果两组患者移植后，粒细胞、血小板的下降与回升有一定规律性，自体移植组和异体移植组中性粒细胞恢复时间分别为14和16d，血小板恢复时间分别为23和27d，两组比较差异均无统计学意义（P〉0．05）。但是无论自体或异体移植组中，外周血移植均较骨髓移植的造血系统重建时间短，差异有统计学意义（P〈0．05）；吸收剂量≥10Gy者血小板重建时间较〈10Gy者缓慢（P〈0．05）；中性粒细胞恢复时间与吸收剂量无关。结论在全身照射剂量条件相同情况下，自体和异体造血干细胞移植后造血系统重建状况差异无统计学意义，但是外周血造血干细胞移植较骨髓移植造血重建迅速，血小板恢复时间与吸收剂量有关。Objective To analyze the clinical outcome of total body irradiation in hematopoiesis reconstruction after autologous and allogeneic hematopoietic stem cell transplantation. Methods 35 patients received autologous hematopoietic stem cell transplantation （ ASCT group ） and 35 patients received allogeneic hematopoietic stem cell transplantation （Allo-HSCT group） were enrolled in this study. And their hematopoiesis reconstruction were observed and analyzed. Results The recovery time of ANC were 14 and 16 d, respectively, and the recovery time of PLT were 23 and 27 d, respectively, the difference were not significant （P 〉 0.05） in ASCT group and Allo-HSCT group. But for both group, hematopoiesis reconstruction were faster in peripheral blood stem cell transplant than those in bone marrow transplant（ P 〈 0.05）. The recovery time of PLT with the patients of total body irradiation dose ≥ 10 Gy were longer than those of 〈 10 Gy. Conclusions At the same doses, the clinical outcome of hematopoiesis reconstruction of ASCT is similar to that of Allo-HSCT. But the recovery time in peripheral blood stem cell transplantation is. faster than that in bone marrow transplant. The recovery time of PLT has relation with the irradiation dose.

关 键 词：造血干细胞移植 自体和异体 外周血干细胞移植 骨髓移植 造血重建 全身照射 

分 类 号：R457.7[医药卫生—治疗学]