吸烟加重高血压病患者大中动脉硬化  

Smoking Aggravates Large and Midio Arterial Stiffness in Patients with Essential Hypertensive

作　　者：丁立群[1] 姜玲[1] 范洁[1] 

机构地区：[1]云南省第一人民医院心内科,云南昆明650032

出　　处：《中华高血压杂志》2008年第1期26-28,共3页Chinese Journal of Hypertension

摘　　要：目的探讨吸烟对高血压病患者大动脉结构和功能的影响。方法用超声检测75例吸烟高血压病患者及70例不吸烟高血压病患者主动脉、颈动脉和肱动脉管径、内膜中膜厚度,内膜中层面积及动脉扩张性、管壁顺应性等指标,用协方差分析校正其它因素的混杂影响后比较吸烟组和不吸烟组动脉结构和功能指标的差异。结果吸烟组主动脉、颈动脉和肱动脉内膜中膜厚度和内膜中层面积显著增加,动脉的扩张性和管壁顺应性降低,即使校正了年龄、体质量指数、心率、血压、脉压、空腹血糖、低密度脂蛋白胆固醇及三酰甘油这些可能影响血管结构和功能的因素后,差异显著性依然存在。结论吸烟加重了高血压患者大中动脉硬化。Objective To investigate the effect of smoking on large arterial stiffness in patients with essential hypertensive. Methods The aortic, carotid and brachial arterial dimension, intimabmedial thickness were determined by vascular ultrasound technique. Wall cross sectional area and indices of compliance and distensibility were calculated in essential hypertensive patients with smoking （n= 75） or without smoking （n= 70）. Results Hypertensive patients with smoking have increased wall intimal-medial thickness and wall cross sectional area in aortic, carotid and brachial arteries associated with decreased compliance and distensibility. After adjusting for the confounding effects of other variables including Age, BMI, HR, BP, PP, FPG, LDL-C and TG, covariance analysis show smoking remained as predisposed factors for vascular remodeling. Conclusion Smoking aggravates large arterial stiffness in essential hypertensive patients.

关 键 词：吸烟 高血压病 大动脉硬化 

分 类 号：R544.1[医药卫生—心血管疾病] R543.5[医药卫生—内科学]