利胆丸药理研究  

Pharmacological Study of Cholagogic Capsule

作　　者：唐春萍[1] 张蜀[1] 何兆红 谭载友[1] 洪江游 骆晓东 吴卓辉 

机构地区：[1]广东药学院药物研究所,广州510224 [2]中瑞医药有限公司

出　　处：《中药材》1997年第3期149-152,共4页Journal of Chinese Medicinal Materials

摘　　要：实验表明:利胆丸可明显增加胆汁流量,但对胆汁成分无明显影响;对ANIT所致大鼠阻塞性黄疸无明显作用;对二甲苯致小鼠耳廓肿胀及大鼠角叉菜胶足跖肿胀均有抑制作用,其抗炎作用可持续4小时以上,明显对抗Ach引起的胆囊肌条收缩活动。结果表明:利胆丸可增加胆汁分泌量,并具有平滑肌解痉和抗炎作用,提示利胆丸对泥沙样胆结石、急慢性胆囊炎等治疗作用与其上述作用有关。Cholagogic capsule is mainly composed of Fiuctus Cardui, Mariae, Oleum Menthae Piperilae, Radix Currmae , olia taraxaci, Oleum Hyperici. It is shown that Cholagogic Capsule increase the rat's bile secretion signifi cantly, but bile component is not influenced effectively, the retention jaundice models of which are created by ANIT isn't influenced effectively. It can reduce the mouse pinna swelling caused by dimelhythenzene and depress the metatarsal swelling induced by carragenin, the antiinflammatory effect keeps for more than 4h. It inhibits the contraction of gallbladder smooth musele of Guinea Fig caused by Ach. The results show that cholagogic Capsule increase bile secretion,antispasmodic and antiinflammatory effect. It is suggested the therapeutic effects of Cholagogic Capsule in sand-like calcul and acute chronic cholecystitis are related to the above pharmaological effects.

关 键 词：利胆丸 抗炎 退黄 解痉 中药药理学 

分 类 号：R285.5[医药卫生—中药学] R286.55[医药卫生—中医学]