不同纯度和浓度橙皮苷对大鼠在体肠吸收比较研究  

Study on absorption of hesperidin of different purities and concentrations in rats′ intestine

作　　者：周扬星[1] 杨中林[1] 

机构地区：[1]中国药科大学教育部现代中药重点实验室,南京210038

出　　处：《药学与临床研究》2008年第1期16-18,共3页Pharmaceutical and Clinical Research

基　　金：科技部十一五科技支撑计划课题(编号:2006BAI06A11-14)

摘　　要：目的:比较研究不同纯度和浓度的橙皮苷在大鼠体肠吸收情况,初步探讨橙皮苷的吸收机理。方法:运用大鼠在体肠灌流模型,收集灌流流出液,并采用HPLC测定橙皮苷和酚红在灌流液中的浓度,对橙皮苷吸收特性进行研究。结果与结论:橙皮苷在大鼠肠道的吸收常数Ka随浓度的升高而显著降低(P<0.01),但纯度升高时Ka降低不显著(P>0.05);橙皮苷提取物中的共存成分可增加其吸收,吸收方式现可排除被动吸收,但有仍待于进一步研究。Objective：To observe the absorption characteristics of different purites and concentrations of hesperidin in rats intestine. Methods： HPLC method was used to determine the concentration of hesperidin in the perfusion which outleted from the opened rat in vivo. Result and Conclusion： A significant increase of in the rat intestine absorption was found when hesperidin were used in low concentrations （P 〈 0. 01 ）. A slight increase （P 〉 0. 05 ） was also observed in the presence of low purity of hesperidin. Therefore, it can be concluded that the components in hesperidin extract appears to be a promising strategy to enhance the intestinal absorption of hesperidin, transportation mechanism need further study, while the passive absorption may be excluded.

关 键 词：橙皮苷 纯度 浓度 在体肠吸收 

分 类 号：R965[医药卫生—药理学]