社区获得性肺炎患者血清可溶性细胞间黏附分子1和可溶性血管细胞黏附分子1的变化及意义  

Significance of serum soluble intercellular adhension molecule-1 and soluble vascular cell adhension molecule-1 in patients with community-acquired pneumonia

作　　者：陈愉生[1] 谢宝松[1] 林明[1] 许能銮[1] 林章树[1] 李瑞慧[1] 李鸿茹[2] 林立芳[3] 

机构地区：[1]福建医科大学省立临床学院福建省立医院呼吸内科,福建福州350001 [2]福建医科大学 [3]福建省心血管病重点实验室

出　　处：《中国呼吸与危重监护杂志》2008年第1期26-29,共4页Chinese Journal of Respiratory and Critical Care Medicine

基　　金：福建省自然科学基金资助项目(编号:F0310043)

摘　　要：目的探讨社区获得性肺炎(CAP)患者可溶性细胞间黏附分子1(sICAM-1)和可溶性血管细胞黏附分子1(sVCAM-1)水平的变化及意义。方法使用酶联免疫吸附(ELISA)双抗体夹心法动态检测25例CAP患者治疗前后情况及10例健康对照组血清sICAM-1、sVCAM-1的水平。结果CAP组患者治疗前sICAM-1和sVCAM-1分别为(2.6584±0.2597)ng/mL、(2.6809±0.2554)ng/mL,对照组sICAM-1和sVCAM-1分别为(2.4728±0.0776)ng/mL、(2.4263±0.3072)ng/mL,两组比较差异均有统计学意义(P<0.01,P<0.05)。CAP组患者治疗后sICAM-1和sVCAM-1分别为(2.5183±0.2052)ng/mL、(2.5230±0.2794)ng/mL,与治疗前比较明显下降,差异有统计学意义(P均<0.01);而与对照组比较差异无统计学意义(P均>0.05)。sICAM-1水平表达与中性粒细胞计数呈正相关(r=0.602,P<0.001);sVCAM-1水平与中性粒细胞计数无明显相关性(r=0.036,P>0.05)。结论社区获得性肺炎患者sICAM-1和sVCAM-1水平随肺炎治疗显效后下降,动态检测血清sICAM-1及sVCAM-1水平有助于判断肺炎病情的转归。Objective To detect the levels and study the significance of serum soluble intercellular adhension molecule-1 （ sVCAM-1 ）, soluble vascular cell adhension molecule-1 （ sVCAM-1 ） in patients with community-acquired pneumonia（CAP）. Methods sICAM-1 and sVCAM-1 were detected by enzymelinked immunosorbent assy（ELISA） in 25 patients with CAP before and after treatment as well as in 10 healthy controls, Results Before treatment,the levels of serum sICAM-1 and sVCAM-1 in the patients with CAP[ （2.658 4 ±0. 259 7）ng/mL, （2. 680 9±0. 255 4）ng,（mL）] were significantly higher than those in controls[ （2. 472 8±0. 077 6） ng/mL, （2. 426 3±0. 307 2） ng/mL] （P 〈0. 01 ,P 〈0. 05）. After treatment, the levels of serum sICAM-1 and sVCAM-1 significantly decreased [（ 2.518 3 ± 0. 205 2）ng/mL, （2. 523 0 ± 0. 279 4）ng/mL] （P 〈 0.01, P 〈 0.01 ）and were not different from those in controls （ P 〉 0.05 ）. The levels of sICAM-1 were positively correlated with neutrophil counts （ r = 0. 602, P〈0.001）rather than the levels of sVCAM-1 （r = 0.036,P 〉0.05）. Condusion The changes of sICAM-1 and sVCAM-1 before and after treatment are predictive to the prognosis in patients with CAP.

关 键 词：社区获得性肺炎 可溶性细胞问黏附分子1 可溶性血管细胞黏附分子1 

分 类 号：R563.1[医药卫生—呼吸系统]