高血压病患者动态血压对左室肥厚及颈动脉内-中膜厚度的影响  

Influence of the ambulatory blood pressure monitoring parameters on left ventricular hypertrophy and carotid artery intima-media thickness in patients with hypertension

作　　者：聂采现[1] 康长明[1] 

机构地区：[1]四川省人民医院,四川成都610071

出　　处：《心血管康复医学杂志》2008年第1期27-30,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨高血压病患者动态血压参数与左室肥厚及颈动脉内-中膜厚度的影响。方法:初诊的高血压病患者125例经超声心动图和颈动脉超声检查被分为颈动脉内-中膜增厚组(n=44例)和无内-中膜增厚组(n=81例);左室肥厚组(n=37例)和无左室肥厚组(n=88例)。测定动态血压参数,血脂、血糖等生化指标,并进行比较。结果:(1)左室肥厚组与无左室肥厚组的临床指标比较差异不显著(P>0.05);(2)左室肥厚组与无左室肥厚组的动态血压参数比较分别为:24h平均收缩压(141.5±13.7)∶(127.5±11.9)mmHg,24h平均舒张压(87.1±8.6)∶(80.9±9.1)mmHg,24h脉压(53.9±10.3)∶(44.9±9.5)mmHg,动态血压非勺型昼夜节律60.3%∶28.7%,其差异均有显著性(P均<0.05);(3)颈动脉内-中膜增厚组与无内-中膜增厚组的上述临床指标比较,差异不显著(P>0.05),而动态血压参数比较差异有显著性(P<0.05)。结论:高血压病动态血压参数对左室肥厚及颈动脉内-中膜增厚有显著影响,可能参与其发病机制。Objective： To investigate the influence of the influence blood pressure monitoring （ABPM） parameters on left ventricular hypertrophy （LVH） and carotid intima-media thickness （IMT） in the patients with hypertension. Methods： The 125 hypertension patients who was never treated regularly before. All patients underwent ultrasound examinations of the heart and the IMT of carotid arteries. They were classified as LVH group （n=37） or no LVH group （n=88）, and as IMT increase group （n=44） or no IMT increase group （n=81）. The ABPM examination were performed in all patients. Then the data comparison was made. Results; （1） The parameters of At3PM in LVH group were higher than those in no LVH group： there were significant differences （P〈0. 05） in 24h mean systolic blood pressure [ （141.5±13.7） ： （127.5±11.9） mmHg], 24h mean diastolic blood pressure [ （87. 1±8.6） ：（80. 9±9. 1） mmHg], the non-dipper rhythm of ambulatory blood pressure （60. 30% ： 28.7%） ; （2） The parameters of ABPM in IMT increase group were higher than those of no IMT increase group （P〈0.05） ; there were no significant differences in clinical manifestations between the IMT increase and no IMT increase group （P〉0.05）. Conclusion： There are significantly influence of ABPM parameters on LVH and IMT of carotid artery. ABPM parameters abnormality may participate the onset of LVH and IMT.

关 键 词：高血压 血压监测 便携式 肥大 左心室 颈动脉 

分 类 号：R544.109[医药卫生—心血管疾病]