去氧孕烯-炔雌醇预治疗在短方案促排卵周期中的应用  

Effect of desogestrel and ethinyl estradiol pretreatment in superovulation cycles with short protocol

作　　者：赵军招[1] 林仙华[1] 黄学锋[1] 林金菊[1] 林文琴[1] 叶碧绿[1] 

机构地区：[1]温州医学院附属第一医院生殖医学中心,325000

出　　处：《中华妇产科杂志》2008年第2期102-105,共4页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的研究去氧孕烯-炔雌醇（DEE）预治疗在短方案促排卵周期中的疗效。方法回顾性分析101例接受体外受精-胚胎移植（IVF-ET）患者的132个短方案促排卵周期，分为两组：研究组42例共56个周期采用DEE预治疗2个月，对照组59例共76个周期未行DEE预治疗。比较两组患者的周期取消率、临床妊娠率、流产率。结果研究组使用DEE预治疗后，血卵泡刺激素水平从11．7U／L降至6．8U／L，差异有统计学意义（P〈0．05）。研究组有3个周期取消，周期取消率为5％，对照组有13个周期取消，周期取消率为17％，两组比较，差异有统计学意义（P〈0．05）。研究组和对照组的临床妊娠率分别为23％（12／53）和17％（11／63），流产率分别为8％（1／12）和18％（2／11），两组患者分别比较，差异均无统计学意义（P〉0．05）。两组患者间获卵数、受精率和卵裂率比较，差异均无统计学意义（P〉0．05）。结论对于短方案IVF-ET周期，DEE预治疗能显著降低周期取消率，有提高临床妊娠率和降低流产率的趋势。Objective To study the effect of desogestrel and ethinyl estradiol （DEE） pre-treatment combined with gonadotropin releasing hormone agonist（GnRH-a） stimulation in in vitro fertilization-embryo transplantation（IVF-ET）. Methods A retrospective analysis was performed in 101 infertile women who received a short protocol of GnRH-a for IVF-ET treatment from June 2004 to June 2007 in the Reproductive Medicine Center of First Affiliated Hospital of Wenzhou Medical College. Patients had been pre-treated with oral contraceptive pill （OCP） for two months before GnRH-a combined with recombinant follicle stimulation hormone （r-FSH） treatment （study group, n =42） or had not been pretreated with OCP（ control group, n = 59）. A statistical analysis of two groups was carried out for the assessment of ovulation stimulating effect of OCP and its influence on the IVF. Results Serum FSH was significantly decreased after OCP in the study group. Twelve pregnancies were obtained including 1 case of spontaneous abortion at 7 weeks in the study group, and 11 pregnancies were obtained including 2 cases of spontaneous abortion during 7 -9 weeks in control group. The clinical pregnancy rates in the study group （23%, 12/53 ） was higher than that in the control group （ 17%, 11/63）, but the differences were not significant （ P 〉 0. 05 ）. The miscarriage rate in the study group （8%, 1/12） was lower than that in the control group （18% ,2/11 ）, however no significant differences were found between them（P 〉0.05 ）. The cycle cancellation rate in patients of the study group （5% ,3/56）was significantly lower than that in patients of the control group （17%, 13/76, P 〈 0. 05 ）. The differences between patients of the two groups with respect to age, basal level of FSH and luteinizing hormone （ LH）, antral follicle counts, the mean number of oocyte retrieval, the days of stimulation, total dose of r- FSH used, fertilization rate and embryo cleavage rate, however were insignificant. Concl

关 键 词：受精 体外 胚胎移植 排卵诱导 临床方案 脱氧孕烯 避孕药 口服 

分 类 号：R686[医药卫生—骨科学]