祛瘀消斑胶囊对高脂血症兔动脉硬化斑块的影响  

Effect of Quyu Xiaoban Capsule on Hyperlipemia Rabbits with Arteriosclerosis Clots

作　　者：刘艳[1] 赵玉霞[1] 燕芳芳[1] 刘运芳[1] 刘文斌[1] 

机构地区：[1]山东大学齐鲁医院中医科,济南市文化西路107号250012

出　　处：《中医杂志》2008年第1期70-71,共2页Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(30472262)

摘　　要：目的观察祛瘀消斑胶囊对高脂血症兔动脉粥样硬化(AS)斑块发展和脂质沉积的干预效果。方法将45只AS模型兔分为中药组、西药组及对照组,检测血清氧化修饰低密度脂蛋白(ox-LDL)和低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)、甘油三酯(TG)水平及HDL-C/LDL-C,测定斑块内脂质沉积面积。结果用药后兔血清ox-LDL、LDL- C、TC和TG的浓度较用药前显著降低,而HDL-C/LDL-C显著升高(P<0.05或P<0.01);与对照组比较,各项检测指标变化均有显著性意义(P<0.05或P<0.01);镜下观察到中药组和西药组脂质沉积面积显著小于对照组。结论祛瘀消斑胶囊能改善血脂异常,减少斑块脂质沉积,有良好的调脂作用。Objective To observe the effect of Quyu Xiaoban Capsule （Capsule for removing blood stasis and eliminate clots） on the development of arteriosclerosis （AS） clots and lipid sediment of rabbit models. Methods The 45 AS rabbit models were divided into Chinese medicine group, western medicine group, and control group. The serum oxidized low density lipoprotein （ox-LDL）, low density lipoprotein cholesterol （LDL-C）, high density lipoprotein cholesterol （HDL-C）, total cholesterol （TG） ,triglyceride （TG）, and the HDL-C/LDL-C were tested to examine the lipin deposition area in the clots. Results After medication, the density of serum ox- LDL, LDL-C, TC and TG was obviously lowered, while HDL-C/LDL-C obviously raised （P〈0. 05 or P〈0. 01）. Compared with the control group, the changes of all indices were significant （P〈0. 05 or P〈0.01）. The lipin deposition area of the Chinese and western medicine groups observed with the microscope was obviously smaller than that of the control group. Conclusion Quyu Xiaoban Capsule can correct the blood fat abnormality, reduce the lipid sediment of clots, having remarkable effect in regulating fatmetablism.

关 键 词：祛瘀消斑胶囊 动脉粥样硬化 脂质沉积 

分 类 号：R285.5[医药卫生—中药学]