内源性阿片样物质对味觉厌恶学习建立和保持的影响  

Effect of endogenous opiate like substance on acquisition and retention of conditioned taste aversion

作　　者：史玉兰[1] 张金平[2] 白文忠[3] 潘培森[1] 金凤霞[3] 

机构地区：[1]白求恩军医学院生理学教研室,河北石家庄050081 [2]河北医科大学组织学与胚胎学教研室,河北石家庄050017 [3]河北师范大学生命科学学院动物生理教研室,河北石家庄050016

出　　处：《第四军医大学学报》2008年第4期302-304,共3页Journal of the Fourth Military Medical University

摘　　要：目的:探讨内源性阿片样物质对于味觉厌恶学习(CTA)建立和保持的影响.方法:将成年雄性SD大鼠分为正常CTA建立组、CTA建立前阿片受体拮抗剂纳洛酮腹腔注射组以及CTA建立后纳洛酮腹腔注射组,以纳络酮为工具进行行为学研究.结果:在动物获得对糖精溶液的CTA后,再次给以糖精溶液,各组大鼠的糖精溶液摄取量均呈逐日增多趋势.在给以糖精溶液前注射纳洛酮的大鼠,CTA消退较慢,而腹腔注射LiCl后20min给以纳洛酮,对CTA的记忆保持无明显影响.结论:内源性阿片样物质可能参与了CTA形成过程的调制作用.AIM： To investigate the effect of endogenous opiate like substance on the acquisition and retention of conditioned taste aversion （CTA） in rats. METHODS： Behavioral experiments were applied, naloxone used as a tool. The adult male SD rats were divided into a normal CTA group （control） and 2 naloxone groups. In the 2 naloxone groups, naloxone as one of effective opiate antagonists was ip injected into rats before or after the acqnisition of CTA individually. RESULTS： When the rats were exposed to saccharin solution after the acquisition of CTA using the same solution , the quantity of the solution intaken by each group increased daily. CTA of the rats with naloxone ip injected after CTA vanished slower than that of control group, while naloxone ip injected 20 min before CTA seemed to have no obvious influence on the retention of CTA. CONCLUSION： Endogenous opiate like substances may be involved in the modulation of the acquisition of CTA.

关 键 词：味觉厌恶学习 纳洛酮 大鼠 脑 

分 类 号：R338.6[医药卫生—人体生理学]