低分子肝素钠与低分子肝素钙治疗不稳定型心绞痛的疗效比较  

Comparison of therapeutic efficacy of low-molecular heparin sodium (Futos) and low-molecular heparin calcium (Fraxiparine) for unstable angina pectoris

作　　者：薛玉生[1] 刘军[1] 何勇[1] 张可超[1] 郭勇[1] 郝红军[1] 

机构地区：[1]第四军医大学唐都医院心内科,陕西西安710038

出　　处：《第四军医大学学报》2008年第4期320-321,共2页Journal of the Fourth Military Medical University

摘　　要：目的:对比观察国产低分子肝素钠(活多史)与进口低分子肝素钙(速碧林)对不稳定型心绞痛(UAP)的疗效及副作用.方法:将60例UAP患者随机分为活多史组与速碧林组(各30例),在常规治疗的基础上分别予以活多史0.4mL(4250U)和速碧林0.4mL(4100U)腹壁皮下注射,2次/d共7d.观察临床显效率、总有效率、急性心肌梗死率、出血事件发生率等.结果:两组对心绞痛的临床显效率、总有效率、急性心肌梗死率、出血事件发生率分别为66.7%(20/30)vs70.0%(21/30),90.0%(27/30)vs93.3%(28/30),3.3%(1/30)vs3.3(1/30),13.3(4/30)vs10.0%(3/30),无统计学差异.结论:国产低分子肝素钠(活多史)是治疗UAP安全、有效的药物.AIM： To observe the efficacy and side effects of lowmolecular heparin sodium（ Futos ） for unstable angina pectoris and compare with that of low-molecular heparin calcium （ Fraxiparine）. METHODS： Sixty patients with unstable angina pectoris were randomly divided into Futos group and Fraxiparine group （ n =30, respectively）. In addition to general treatments, they were given abdominal subcutaneous injection of Futos 0.4mL（4250 U） or Fraxiparine 0.4 mL（4100 U）, two times per day for 7 d. The marked efficiency rates, total efficiency rates, acute myocardial infarction rates and bleeding event rates were observed. RESULTS： In Futos group and Fraxiparine group, the marked efficiency rates, total efficiency rates, acute myocardial infarction rates and bleeding event rates were respectively 66.7% （20/30） vs 70.0% （21/30）, 90.0% （27/30） vs 93.3% （28/30）, 3.3% （1/30） vs3.3%（1/30）, 13.3% （4/30） vs 10.0%（3/30）, and there was no statistically significant differences. CONCLUSION： Homemade low-molecular heparin sodium （Futos） is a safe and effective drug for the patients with unstable angina pectoris.

关 键 词：低分子肝素钠 心绞痛 不稳定型 

分 类 号：R5[医药卫生—内科学]