N-乙酰半胱氨酸治疗特发性肺纤维化的疗效观察  

The N-acetyl Cysteine Treatment Idiopathic Pulmomary Fibrosis Curative Effect Observation

作　　者：赵琦[1] 吕福祯[1] 毛梓源[2] 

机构地区：[1]哈尔滨医科大学第二临床医学院,黑龙江哈尔滨150080 [2]黑龙江省森工总医院,黑龙江哈尔滨150040

出　　处：《黑龙江医学》2008年第1期30-31,共2页Heilongjiang Medical Journal

摘　　要：目的探讨特发性肺纤维化患者长期大量口服N-乙酰半胱氨酸对动脉血氧分压(PaO2)及临床症状的影响。方法确诊的30例特发性肺纤维化患者随机分为两组,对照组常规给予泼尼松口服,治疗组给予口服泼尼松加N-乙酰半胱氨酸600 mg/次,3次/d,连续服用6个月。分别于治疗前、治疗第4,8,12周测定PaO2及观察临床症状的缓解情况。结果30例特发性肺纤维化患者入院时均有干咳、呼吸困难症状,测定PaO2均有下降。其中Ⅰ型呼吸衰竭患者19例,经过治疗,PaO2有不同程度的升高,临床症状改善。两种治疗方法相比较,治疗组较对照组治疗效果有显著性。结论长期大量口服N-乙酰半胱氨酸对改善特发性肺纤维化患者临床症状及提高PaO2有较好的治疗效果。Objective The discussion sends the lung fibrosis patient to take orally the N- acetyl systeine different treatment course especially to PaO2 and the clinical symptom influence.Methods The diagnosis 30 examples send the lung fibrosis patient to divide into two groups stochastically especially, the control group convention give Prednisone to take orally, the treatment rents to gives takes orally Prednisone to add the N - acetyl cysteine 600 milllgrams/time, daily three times, takes continuously for 6 months.Separately before the treatment, treats 4th week,8th week, the 12th week observation clinical symptom alleviation situation and determines Pa02. Results 30 examples send when especially the lung fibresis patient in hospital has coughs without expectorating, the breath difficult symptom, determines PaO2 to have the drop.In which Ⅰ breath failure patient 19 examples.Mter the treatment, PaO2 has the varying degree ascension,clinical symptom improvement. Two methods of treatment compare, the treatment group compares the control group treatment resuit to have the significance. Conclusion Longterm takes orally the N- acetyl cysteine to improve massively especially sends the lung fibrosis patient clinical symptom and enhances PaO2 to have the good treatment result.

关 键 词：特发性肺纤维化 动脉血氧分压 N-乙酰半胱氨酸 

分 类 号：R563[医药卫生—呼吸系统]