糖尿病微血管病变患者血栓前状态标志物的改变与抗心磷酯抗体变化的关系  

Study on the relationship between changes of markers in prothrombotic state and anti-cardiolipin antibody in patients with diabetic microangiopathy

作　　者：刘燕婕[1] 胡丽华[1] 陈凤花[1] 徐磊[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院检验科,武汉430022

出　　处：《临床血液学杂志（输血与检验）》2008年第1期73-75,共3页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

摘　　要：目的:探讨糖尿病微血管病变(DMA)患者血栓前状态标志物的改变及与自身抗体产生的关系。方法:采用免疫比浊法测定血浆纤维蛋白原(Fbg),酶联免疫吸附法(ELISA法)测定血浆中外周血浆因子Ⅷ相关抗原(VWFAg)、D-二聚体((D-D)和抗心磷酯抗体(ACA)在DMA组、糖尿病无微血管病变组和正常组中的含量。结果:DMA组血浆中血栓前状态标志物Fbg、VWFAg及D-D和自身抗体ACA的水平明显高于糖尿病无微血管病变组和正常组(P<0.05或P<0.001),ACA水平的增高与Fbg、VWFAg及D-D水平的增高呈正相关,且ACA在DMA组中的阳性率显著高于糖尿病无微血管病变组和正常组(P<0.05)。结论:糖尿病患者存在着凝血和纤溶功能的改变,在DMA时Fbg、VWFA、D-D等血栓前状态标志物增高更明显,与血栓形成密切相关的自身抗体ACA在DMA时的阳性率明显增高,且与Fbg、VWFA、D-D的增高呈正相关。因此,检测DMA患者的Fbg、VWFA、D-D和ACA水平对预防和治疗血栓形成及预后判断具有一定的临床意义。Objective：To explore the relationship between changes of markers in prothrombotic state and autoantibodies in patients with diabetic microangiopathy （DMA）. Methods.. The plasma levels of fibrinogen （ Fbg）, VWFAg,D-dimer（D-D） and anti-cardiolipin antibody（ACA） were detected in the patients with DMA, the patients without DMA and the healthy controls. The Fbg was measured by immunoturbidimetry and the VWFAg, D-D and ACA were measured by enzyme-linked immunosorbent assay（ELISA）. Result：The levels of Fbg, VWFAg , D-D and ACA in the patients with DMA were significantly higher than those of the patients without DMA and the healthy controls（ P〈0.05 or P〈0. 001）. The enhancement of ACA was correlated with the enhancement of levels of Fbg, VWFAg and D-D, and thee positive ratio of ACA in the patients with DMA was significantly higher than that of the patients without DMA and the healthy controls. Conclusion：The patients with DM had changes in blood clotting and fibrinolysis. The levels of Fbg, VWFAg and D-D were significantly enhanced in patients with DMA. The positive ratio of ACA that was associated with thrombopoiesis was significantly enhanced in patients with DMA and associated with the enhancement of the levels of Fbg, VWFA and D-D. Therefore, it is of certain clinical significance in preventing and curing thrombopoiesis and judging prognosis to detect the levels of Fbg, VWFA, D-D and ACA in the patients with DMA.

关 键 词：糖尿病微血管病变 血栓前状态标志物 抗心磷脂抗体 

分 类 号：R587.1[医药卫生—内分泌]