流行性出血热患者血清TNF-α水平的变化及临床意义  

Clinical significance of serum TNF-α in patients with epidemic hemorrhagic fever

作　　者：汪建宏 吴卫春[2] 张丽萍[2] 鲍芹仙 

机构地区：[1]开化县人民医院,324300 [2]杭州师范大学医学院附属余杭医院

出　　处：《浙江医学》2008年第1期32-33,40,共3页Zhejiang Medical Journal

摘　　要：目的探讨流行性出血热(HFRS)患者血清TNF-α水平的变化及其临床意义。方法采用ABC-HRP法检测轻中型、危重型组HFRS患者及对照组血清TNF-α水平并观察其动态变化,同时检测尿蛋白(UP)和血PLT、BUN及Cr水平。结果轻中型及危重型组HFRS患者血清TNF-α水平均明显高于对照组(P<0.01),且危重型组TNF-α水平增高幅度明显大于轻中型组(P<0.01),且持续时间明显长于轻中型组(P<0.01)。TNF-α水平与UP、BUN及Cr水平呈正相关,与PLT水平呈负相关。结论HFRS患者病情严重程度与TNF-α水平关系十分密切。早期检测TNF-α及UP、BUN、PLT等的水平有助于HFRS的诊断,连续动态观察有利于监测病情和评估预后。Objective To investigate serum TNF-α levels in patients with epidemic hemorrhagic fever （HFRS） and its clinical significance. Methods Serum TNF-alevels were determined with ABC-HRP method in patients with HFRS. Platelet count （PLT）, urinary proteins （UP）, blood urea nitrogen （BUN） and serum creatinine （Cr） were also determined. Results Serum TNF-α levels of HFRS patients were significantly higher than those of the controls （P〈0.01）. The levels of serum TNF-α in severe and critical group were higher than those in the mild and moderate group （P〈0.01）. UP, BUN and Cr were positively correlated with serum TNF-α levels. The PLT count was negatively correlated with serum TNF-α levels. Conclusion Serum TNF-α levels are closely related to the condition of patients with HFRS. Dynamic observation of serum TNF-α with UP and PLT determination may be helpful for early diagnosis, disease surveillance and prognosis of patients with HFRS.

关 键 词：流行性出血热 TNF—α 血小板 尿蛋白 

分 类 号：R512.8[医药卫生—内科学]