Water promoted, microwave-assisted oxidative novel deamination of N-aminoquinazolinones  

作　　者：M. Arfan Rasool Khan Shazia Anjum Shabir Ahmad M. Iqbal Choudhary 

机构地区：[1]Institute of Chemical Sciences, University of Peshawar, Peshawar 25120, Pakistan [2]HEJRIC, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan

出　　处：《Chinese Chemical Letters》2008年第2期161-165,共5页中国化学快报（英文版）

摘　　要：A novel deamination of 2-alkyl/aryl 3-amino-4（3H）-quinazolinones series using aqueous KMnO4 under thermal condition and microwave irradiation is described. Compared to thermal condition, significantly higher yields in much shorter times were observed for reactions under microwave irradiation. A plausible mechanism has been proposed for the oxidative water-promoted deamination.A novel deamination of 2-alkyl/aryl 3-amino-4（3H）-quinazolinones series using aqueous KMnO4 under thermal condition and microwave irradiation is described. Compared to thermal condition, significantly higher yields in much shorter times were observed for reactions under microwave irradiation. A plausible mechanism has been proposed for the oxidative water-promoted deamination.

关 键 词：N-Aminoquinazolinones Oxidative deamination KMNO4 WATER Microwave irradiation 

分 类 号：O621.2[理学—有机化学]