Synthesis of urea acetates as potential PPARα/γ dual agonists  

作　　者：Chang Yan Zhao Chang Qing Shi Yuan Wei Chen 

机构地区：[1]Key Laboratory of Asymmetric Synthesis ＆ Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China [2]Graduate School of Chinese Academy of Sciences, Beijing 100049, China

出　　处：《Chinese Chemical Letters》2008年第2期166-168,共3页中国化学快报（英文版）

摘　　要：In the quest for novel PPARα/γ dual agonists as putative drugs for the treatment of type 2 diabetes and dyslipidemia, we designed and synthesized a series of urea acetates as potential PPARα/γ dual agonists. The structure of the target compounds, intermediates were characterized by ^1H N-MR, HRMS.In the quest for novel PPARα/γ dual agonists as putative drugs for the treatment of type 2 diabetes and dyslipidemia, we designed and synthesized a series of urea acetates as potential PPARα/γ dual agonists. The structure of the target compounds, intermediates were characterized by ^1H N-MR, HRMS.

关 键 词：Oxazolc PPAR agonist Type 2 diabetes UREA AMMONOLYSIS Synthesis 

分 类 号：TQ46[化学工程—制药化工]