多巴胺D_2受体显像剂^(125)I-IBZM的合成与标记  

SYNTHESIS AND LABELLING OF DOPAMINE D 2 RECEPTOR IMAGING AGENT 125 I IBZM

作　　者：胡名扬[1] 梁高林[1] 潘尚仁[1] 

机构地区：[1]江苏省原子医学研究所

出　　处：《核化学与放射化学》1997年第2期53-56,共4页Journal of Nuclear and Radiochemistry

摘　　要：合成了标记前体Ｓ－（－）－２－羟基－６－甲氧基－Ｎ－［（１－乙基－２－吡咯烷基）甲基］苯甲酰胺（Ｓ－（－）－ＢＺＭ）。光谱数据与结构相符。以Ｓ－（－）－ＢＺＭ为前体，用１２５Ｉ－ＮａＩ标记，成功地制备了Ｓ－（－）－３－１２５Ｉ－２－羟基－６－甲氧基－Ｎ－［（１－乙基－２－吡咯烷基）甲基］苯甲酰胺（Ｓ－１２５Ｉ－ＩＢＺＭ）。标记率大于８０％，放射化学纯度大于９０％，整个制备过程仅需４５ｍｉｎ，利于药盒化生产。This paper reports syntheses of labelling precursor S (-) 2 hydroxy 6 methoxy N [(1 ethyl 2 pyrrolidinyl)methyl]benzamide( S BZM).The chemical structure is confirmed by spectral data.Using H 2O 2 as oxidizing agent, S BZM is labelled by 125 I NaI at room temperature. S (-) 3 125 I iodo 2 hydroxy 6 methoxy N [(1 ethyl 2 pyrrolidinyl)methyl]benzamide ( S 125 I IBZM) is successfully prepared.Labelling process is simple,the labelling yield is higher than 80%,the radiochemical purity is higher than 90%.

关 键 词：IBZN 碘125 多巴胺受体 标记 造影剂 显像剂 PET 

分 类 号：R817.9[医药卫生—影像医学与核医学]