保乳术和根治术治疗乳腺癌综合评价  

Comprehensive Evaluation of Radical-Conserving Surgery in the Treatment of Breast Cancer

作　　者：郭良峰[1] 王先明[1] 何劲松[1] 李戎[1] 朱国献[1] 

机构地区：[1]深圳市第二人民医院乳腺外科,深圳518035

出　　处：《中国现代医生》2007年第12Z期32-33,57,共3页China Modern Doctor

摘　　要：目的评价早期乳腺癌行保乳手术加术后放、化疗综合治疗的疗效。方法I、II期乳腺癌患者行保留乳房的肿瘤切除加腋窝淋巴结清除术患者40例(保乳组),同期行乳腺癌改良根治术患者40例(对照组),术后早期予以全身化疗、全乳腺区放疗和(或)内分泌治疗。结果全部病例中位随访53个月,保乳组中无局部复发者,对照组局部复发1例;保乳组和对照组的3和5年生存率分别为94.2%(33/35)和88.0%(22/25),P=0.9878;94.1%(32/34)和87.5%(21/24),P=0.9980;远隔脏器转移率分别为7.5%和5.3%,P=0.9794。两组间各项指标比较差异均无统计学意义,患侧乳房外形的优良率达96.2%。结论早期乳腺癌采用保留乳房手术加术后放、化疗综合治疗,疗效与根治术相似,美容效果好,可作为首选方法之一。Objective To study the feasibility of chemo-radiotherapy for early stage breast cancer after breast-conserving surgery （BCS）. Methods All the cases were Ⅰ,Ⅱ stage of breast cancer, 40 cases underwent conserving surgery（BCS group） while 40 cases, as acontrol, underwent modifiedradicalmastectomy（control group）, followed by radiotherapy, chemotherapy and/or TAM therapy. Results All cases were followed up for 53 months. In BCS group,no patient had local recurrence while 1 patient had local recurrence in the control group. The 3-years,5-years survival rates and distant metastasis rates in BCS group and control group were 94.2%（33/35）vs. 88.0%（22/25）,P=0.9878; 94.1%（32/34）vs. 87.5%（21/24）,P=0.9980,respectively. There were no significant differences between two groups about very previous rate. According to the medical criterion the satisfied with the better shape of the suffered breast was about 96.2%. Conclusion Combined chemo-radiotherapy with breast-conserving surgery for early stage breast cancer may achieve not only similar results as traditional masteetomy with the same treatment protocol,but also can keep a better shape of the breast. It may he considered as one of the primary treatment options.

关 键 词：乳腺肿瘤治疗 综合疗法 乳房切除术 改良根治术 

分 类 号：R655.8[医药卫生—外科学]