聚氯乙烯膜氧氟沙星和曲马多选择电极的研制与应用  

Preparation of Polyvinyl Chloride Membrane Ofloxacin and Tramadol Selective Electrode and Its Application

作　　者：汪敏[1] 龙云[1] 李东辉[1] 周万彬[1] 赵桂芝[1] 张祯[2] 

机构地区：[1]锦州医学院,锦州121001 [2]锦州环保研究所,121000

出　　处：《分析化学》1997年第4期448-451,共4页Chinese Journal of Analytical Chemistry

摘　　要：报道了以氧氟沙星碘化物与碘化铋的分子缔合物为电活性物的新型聚氯乙烯膜氧氟沙星选择电极。并以类似的方法报道了曲马多选择电极。氧氟沙星电极的能斯特响应范围为１．０×１０－２～２．２×１０－５ｍｏｌ／Ｌ；斜率为３０ｍＶ／ＰＣ；检测限为１．６×１０－５ｍｏｌ／Ｌ。曲马多选择电极的能斯特响应范围１．０×１０－１～６．３×１０－６ｍｏｌ／Ｌ；检测限为３．２×１０－６ｍｏｌ／Ｌ。此电极响应迅速，重现性好。用上述电极以标准曲线法分别对药片中的氧氟沙星和注射液中的曲马多进行了测定，结果与紫外分光光度法相符。The construction and performance characteristics of a PVC membrane ofloxacin and tramadol ion selective electrode were reported. The ofloxacin electrode showed Nernast response for ofloxacin with a slope of 30 mV/pC over the concentration range of 1. 0?0-2- 2. 2 ?0-5 mol/L. The detection limit is 1. 6?0-5 mol/L. The tramadol electrode showed Nernst response for tramadol with a slope of 57 mV/pC over the concentration range of 1. 0 ?0-1-6. 3?0-6 mol/L. The detection limit is 3. 2?0-6 mol/L. The results of determi- nation of ofloxacin and tramadol were in agreement with those of ultraviolet spectropho- tometry.

关 键 词：离子选择电极 氧氟沙星 曲马多 氟嗪酸 

分 类 号：R978[医药卫生—药品]