原发胃癌中p15、p16基因蛋白的表达及临床意义  

The Clinical Significance and Expression of p15 as Well as p16 in Primary Gastric Cancer

作　　者：高云升 

机构地区：[1]盖州市中心医院普通外科,辽宁盖州115200

出　　处：《辽宁医学院学报》2007年第6期66-67,共2页Journal of Liaoning Medical University (LNMU) Bimonthly

摘　　要：目的检测原发胃癌原发灶及癌旁正常组织中p15、p16基因蛋白表达情况,探讨p15、p16基因失活与胃癌发生发展及临床病理特征的关系。方法应用免疫组织化学方法检测32例进展期胃癌石蜡标本中p15、p16的表达,并探讨其表达与临床病理特征之间的关系。结果p16、p15在原发灶与癌旁正常组织中阳性表达率差异有统计学意义(P<0.05),p15、p16基因表达在有无淋巴结转移扣不同TNM分期的病例之间差异均有统计学意义(P<0.05)。结论p15、p16蛋白表达可能与胃癌癌变过程相关,并可以作为临床治疗提供理论依据。Objective To test the expression of p15 and p16 in primary gastric cancer and its normal tissue and to discuss the relation between thc genetic losing activity of p15 together with p16 and the development of gastric cancer as well as the features of clinical pathology. Methods 32 cases of the expression of p15 and p16 in samples of paraffin wax of gastric cancer were tested by immunohistochemistry method and tried to discuss the relationship between the expression of p15 and p16 and the features of clinical pathology. Results It had the significance in terms of statistics in the difference in positive expression rates of p15 and p16 in primary gastric carcinoma and normal tissue of adjacent to cancer （ P 〈 0. 05 ） as well as the difference between the cases with lymphnode metastasis or not and different clinical pathological stages （ P 〈 0. 05 ）. Conclusions The protein expression of p15 and p16 may be related to the cancerization of gastric cancer, and it can be used for providing the theoretical evidence as the clinical treatment.

关 键 词：胃肿瘤 免疫组织化学 P15 P16 

分 类 号：R656.6[医药卫生—外科学]