高血压脑出血患者血肿冲洗液IL-1 IL-6及TNF-α含量的动态变化及意义  

Changes of IL-1,IL-6 and TNF-ɑ in hematomal fluid of patients with cerebral hemorrhage

作　　者：李银[1] 李新军[2] 

机构地区：[1]河北北方学院附属第二医院神经内科,河北张家口075100 [2]河北北方学院附属第二医院心内科,河北张家口075100

出　　处：《中国急救医学》2008年第2期155-157,共3页Chinese Journal of Critical Care Medicine

摘　　要：目的研究高血压脑出血患者血肿冲洗液(白细胞介素-1)IL-1、(白细胞介素-6)IL-6及(肿瘤坏死因子-α)TNF-α含量变化及其意义。方法我们用双抗体夹心ELISA法对47例高血压脑出血患者的血肿冲洗液分别在发病第1、3及7天进行了连续检测,并用47例健康人做对照。结果发现高血压脑出血患者血肿冲洗液IL-1、IL-6及TNF-α含量在3个时间点均高于对照组(P<0·05)。在病程第3天血肿冲洗液IL-1、IL-6及TNF-α含量高于第1天和第7天(P<0·05)。结论高血压脑出血患者血肿冲洗液IL-1、IL-6及TNF-α参与了脑出血病理生理过程,与疾病的转归有关。Objective To study the change of IL - 1, IL - 6 and TNF - α in hematomal fluid of the patients with cerebral hemorrhage. Methods In the hematomal fluid, IL - 1, IL - 6 and TNF - α were measured by ELISA in 47 patients with cerebral hemorrhage at 1st, 3rd, 7th and in 47 normal control. Results The levels of IL - 1, IL - 6 and TNF - α in hemorrhage group were significantly higher at all the time points than those in the control （ P 〈 0. 05 ）. The peak was at 3rd day. Conclusion IL - 1, IL - 6 and TNF - α in hematomal fluid was involved in the pathological process of cerebral hemorrhage and was relevant to the prognosis of hypertensive cerebral hemorrhage.

关 键 词：脑出血 微创术 白细胞介素-1 白细胞介素-6 肿瘤坏死因子-α 

分 类 号：R544.1[医药卫生—心血管疾病] R743.3[医药卫生—内科学]