毫米波治疗颈部急性放射性皮肤溃疡：随机对照2个月随访  

Millimeter wave in the treatment of acute radiation-induced cervical skin ulcers:A 2-month randomized controlled follow-up

作　　者：李旭红[1,2] 唐劲天[3] 廖遇平[1] 金和坤[1] 周菊梅[1] 王桂华[1] 王晖[1] 

机构地区：[1]中南大学湘雅医院肿瘤科,湖南省长沙市410008 [2]中南大学湘雅三医院康复科,湖南省长沙市410013 [3]清华大学物理与工程研究所,北京市100084

出　　处：《中国组织工程研究与临床康复》2008年第4期663-666,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：湖南省卫生厅科研基金资助项目(C2006-022)~~

摘　　要：目的:毫米波是无线电波中波长最短、频率最高的一个波段,近年来已用于恶性肿瘤的治疗。实验拟证实毫米波治疗颈部急性放射性皮肤溃疡的疗效,并观察其不良反应。方法:选取2004-06/2007-01在中南大学湘雅医院肿瘤科接受鼻咽癌根治性放疗后的颈部急性放射性溃疡患者54例,所有患者按美国肿瘤放射治疗协作组(RTOG)分级标准评判为Ⅱ～Ⅳ度。将54例患者投币法随机分为2组:①毫米波组:28例,给予毫米波和常规治疗,毫米波治疗采用北京中成康富科技有限公司产MMW-1型毫米波治疗仪,输出功率50mW,波长8.3mm,频率36GHz,每次照射剂量0.78J/cm2,毫米波治疗1次/d,贴近皮肤,30min/次,10d为1个疗程,如病灶未愈合可多程照射。②对照组:26例,接受毫米波安慰性照射和常规治疗,毫米波探头置于与毫米波治疗相同的部位,但不予以输出,治疗时间、频次等均与毫米波组相同。随访2个月,比较两组患者溃疡愈合情况和愈合时间。结果:54例患者均进入结果分析。毫米波组治疗颈部急性放射性皮肤溃疡的有效率为93%(26/28),高于对照组65%(17/26),差异有显著性意义(P<0.05);毫米波组溃疡愈合时间明显短于对照组[(14.30±2.41),(25.33±2.00)d,P<0.01]。两组间不良反应比较差异无显著性意义。结论:毫米波照射可有效促进急性放射性皮炎的伤口愈合,缩短放射性皮肤溃疡的愈合时间。AIM： Millimeter wave is a frequency range with short wave-length and high frequency in radio wave. It has been used in the treatment of malignant tumor recently. This study was to evaluate the efficacy of millimeter wave in the treatment of acute radiation-induced cervical skin ulcers and observe the adverse events. METHODS： Fifty-four patients with acute radiation-induced cervical skin ulcers after radiotherapy of nasopharyngeal cancer were enrolled at the Department of Oncology, Xiangya Hospital, Central South University from June 2004 to January 2007. All patients were assessed as Ⅱ-Ⅳ degree according to the grading standards of Radiation Therapy Oncology Group. The patients were randomly divided into 2 groups. ①Twenty-eight patients in a millimeter wave group received millimeter wave and routine therapy. MMW-1 millimeter wave therapy apparatus was produced by Beijing Zhongcheng Kangfu Technology Co., Ltd. The parameters of the apparatus were frequency 36 GHz （corresponding 8.3 mm） and output power 50 mW, once 0.78 J/cm^2, once a day, nearby skin, once for 30 minutes, 10 days as a course. An additioned course could be performed depending on the dermatitis healing. ②Twenty-six patients in the control group received placebo millimeter wave therapy and routine therapy. Detecting head of millimeter wave was located at the same place of millimeter wave therapy, but did not output, with the same therapeutic time and frequency. Ulcer healing and healing time were compared between the two groups in the 2-month follow-up. RESULTS： Fifty-four patients were involved in the result analysis. The effective rate 93% （26/28） in the millimeter wave group was higher than that in the control group 65% （17/26） （P 〈 0.05）. The healing time of the acute radiation-induced skin ulcers was shorter in the millimeter wave group than in the control group [（14.30±2.41）,（25.33±2.00）d,P 〈 0.01]. There was no significant difference in adverse effects between the two groups. CONCLUSION： Mill

关 键 词：毫米波 放射性皮炎 鼻咽癌/放射治疗 不良反应 

分 类 号：R818[医药卫生—放射医学]