2006年浙江省流行性脑脊髓膜炎监测结果分析  

Analysis of surveillance results on epidemic cerebrospinal meningitis in Zhejiang province in 2006

作　　者：赵艳荣[1] 李倩[1] 张政[1] 徐宝祥[1] 唐学雯[1] 凌罗亚[1] 

机构地区：[1]浙江省疾病预防控制中心,浙江杭州310009

出　　处：《疾病监测》2008年第1期11-13,共3页Disease Surveillance

摘　　要：目的了解2006年浙江省流脑流行病学特征及流脑菌株的药物敏感性特点。方法对2006年全省上报的流脑病例进行描述流行病学分析。设立3个监测点进行健康人群抗体水平和带菌率检测,并对分离到的流脑菌株进行抗生素的耐药性检测。结果2006年浙江省流脑发病率为0.16/10万,病例以A群为主,同时存在C群和B群病例。健康人群中A群抗体保护率(70.65%)远远高于C群(6.52%),流脑菌株带菌率为1.71%,B群占62.50%。所有菌株均对青霉素、氯霉素等9种抗生素敏感,部分菌株对复方新诺明、左氧氟沙星、环丙沙星耐药,且不同血清群、不同来源菌株的耐药程度不同。结论浙江省流脑病例以A群为主,C群比例有上升趋势。流脑菌株对一些抗生素具有耐药性,需全面监测病例和健康带菌者流脑菌株的耐药性特征。Objective The present study was designed to gain an insight into the epidemiological characteristics of epidemic cerebrospinal meningitis in Zhejiang province in 2006 and the sensitivity of Neisseria meningitidis（Nm） strains to some drugs. Methods Descriptive epidemiological analysis was conducted on the data of the cases reported in 2006 in Zhejiang province. Three counties were chosen for the surveillance of serum antibody and Nm carriage rate in general population. The antibiotic resistance of 51 strains, isolated from the patients and healthy carriers with the micro broth dilution method, to sulfanilamide, penicillin, and chloromycetin,etc, was measured. Results The reported incidence rate of epidemic cerebrospinal meningitis was 0.16/lakh populations. Serogroup A was found to be the major cause in most cases, with serogroup C and B and involved in some cases. The protective rate of antibody against serogroup A （70.65%） was much higher than against serogroup C （6.52%） in general population. The carriage rate of Nm in general population was 1.71% with serogroup B being the dominant serogroup （62.50%）. All isolates were sensitive to penicillin, chloromycetin and seven other antimicrobial agents. Some of them were resistant to sulphanilamides, levofloxacin, and ciprofloxacin with different extents of resistance for different serogroups and strains from different sources. Conclusion Serogroup A was still the dominant strain among the confirmed cases with a trend of increasing in serogroup C in Zhejiang province. Serogroup A ＆ C strains were different in sensitivity to various antimicrobial agents. Detection of resistance of the strains associated with epidemic cerebrospinal meningitis in patients with the disease and healthy carriers contributes to effective control and prevention of the epidemic.

关 键 词：流脑 流行病学 监测 

分 类 号：R515.2[医药卫生—内科学]